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MetabolomicsHigh fat diet and sciatic nerves functions
Not available
ORGANISM(S): Mus musculus 
ST000780 | MetabolomicsWorkbench
TranscriptomicsTimecourse expression data from sciatic nerve distal stump of C57BL/6 and C57BL/6 OlaHsd-Wlds mice.
Wallerian degeneration (WD) involves the fragmentation of axonal segments disconnected from their cell bodies, segmentation of the myelin sheath, and removal of debris by Schwann cells and immune cells. The removal and downregulation of myelin-associated inhibitors of axonal regeneration and synthes...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-22291 | biostudies-arrayexpress
TranscriptomicsThe RNA-binding protein HuR coordinates global changes in gene expression during patterning of early peripheral nerves
Identify mRNA targets of the RNA-binding protein HuR in vivo during Schwann cell development using RIP-chip analysis. IP protocol of endogenous mRNA-transfected HuR complexes was performed as described in Keene et al. (2006). In brief, 500 mg of whole-cell lysate obtained from a pool of NB or P5 sci...
ORGANISM(S): Mus musculus 
2012-01-19 | E-MEXP-3519 | biostudies-arrayexpress
TranscriptomicsRNAseq of sciatic nerve from WT versus Adar1cKO mice
Identification of deregulated transcripts in sciatic nerves of Adar1cKO mice versus WT to identify origin of myelin defects observed upon invalidation of ADAR1 in neural crest cells
ORGANISM(S): Mus musculus 
2023-11-03 | E-MTAB-11197 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of sciatic nerves from Zeb2cKO and control mice
We performed gene expression pofiling of Zeb2cKO and control sciatic nerves and identified significantly changed genes ZEB2 is also known as SIP1 4 RNA-Seq samples from P7 sciatic nerves of Ctrl and Zeb2 cKO mice (duplicatess, Ctrl and cKO)
ORGANISM(S): Mus musculus 
2016-06-13 | E-GEOD-74381 | biostudies-arrayexpress
TranscriptomicsGene expression signatures following nerve injury in a rat model (0h-9h)
We used microarrays to distinguish the gene expression differences among different time points after injury. We generated proximal sciatic nerve (SN) tissues (0.5cm) at 0h, 0.5h, 1h, 3h, 6h and 9h after sciatic nerve resection.
ORGANISM(S): Rattus norvegicus 
2012-12-20 | E-GEOD-33175 | biostudies-arrayexpress
TranscriptomicsExpression data of sciatic nerves from mice with Schwann-cell specific Sip1 deletion compared to control mice.
Schwann cell maturation is tightly controlled by a set of transcriptional regulators. We have deleted the zinc-finger transcription factor Sip1 specifically from immature Schwann cells and observed a dramatic developmental delay. In an attempt to define the developmental stage of Sip1-deficient Schw...
ORGANISM(S): Mus musculus 
2016-06-13 | E-GEOD-76027 | biostudies-arrayexpress
Transcriptomicsmouse sciatic nerve profile of CMT1A peripheral neuropathy model, caused by PMP22 overexpression
profiles of normal and diseased sciatic nerve of young adult mice Keywords: other
ORGANISM(S): Mus musculus 
2004-11-12 | E-GEOD-1962 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 8 months and 24 months old rat radial and sciatic nerves
The objective of this study was to determine which pathways are significantly regulated with age in sciatic and radial nerves, individually or considering the interaction term. We find a strong signature of the cholesterol biosynthesis pathway being downregulated with age in both nerves, however, th...
ORGANISM(S): Rattus norvegicus 
2016-05-12 | E-GEOD-77022 | biostudies-arrayexpress
TranscriptomicsSolexa sequencing of small RNAs in Sprague-Dawley (SD) rat [proximal sciatic nerve]
We applied Solexa sequencing technology to identify rat microRNA genes in proximal sciatic nerve following sciatic nerve resection. Using Solexa sequencing, computational analysis and Q-PCR verification, 93 novel miRNAs in rats were discovered and identified, of which 42 novel miRNAs were first repo...
ORGANISM(S): Rattus norvegicus 
2012-05-06 | E-GEOD-26753 | biostudies-arrayexpress
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