Sort   by:  
 Page size 
ProteomicsMouse multi-organ age-associated protein changes across life stages
Ageing is a key risk factor for disease and mortality in humans and other animals, with most insights derived from genomic, epigenomic, and transcriptomic studies. However, large-scale datasets on age-related changes at the protein level remain scarce. To fill this gap, we performed a comprehensive ...
ORGANISM(S): Mus Musculus (mouse) 
2025-06-17 | PXD058684 | JPOST Repository
ProteomicsThe senescence-associated cell surfaceome reveals potential senotherapeutic targets in human and mouse cells
Excessive accumulation of senescent cells contributes to a wide range of physiological declines and age-related pathologies. Senotherapy targeting senescent cell surface molecules represents an attractive approach to eliminate senescent cells with high specificity and accessibility. However, the com...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2025-01-26 | PXD048921 | JPOST Repository
ProteomicsActin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology
Abnormal intraneuronal accumulation of soluble and insoluble alpha-synuclein (alpha-Syn) is one of the main pathological hallmarks of synucleinopathies, such as Parkinson’s disease (PD). It has been well- documented that the reversible liquid-liquid phase separation of alpha-Syn can modulate synapti...
ORGANISM(S): Homo Sapiens (human) Caenorhabditis Elegans 
2025-03-22 | PXD050719 | JPOST Repository
Sort   by:  
 Page size