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TranscriptomicsTranscription profiling of human monocytes after treatment vehicle, isotype control antibody, TREM1 antibody, LPS, isotype control antibody plus LPS and TREM1 antibody plus LP to invesigate innate immune responses to TREM-1 activation
TREM-1 is an orphan immunoreceptor expressed on monocytes, macrophages, and neutrophils. TREM-1 associates with and signals via the adapter protein DAP12/TYROBP, which contains an immunoreceptor tyrosine-based activation motif (ITAM). TREM-1 activation by receptor cross-linking is pro-inflammatory, ...
ORGANISM(S): Homo sapiens 
2008-04-05 | E-GEOD-9988 | biostudies-arrayexpress
TranscriptomicsKRAS-induced transcription analysis in immortalized pancreatic cells
We utilized non-transformed, human pancreatic ductal epithelial (HPDE) cells, previously engineered with the E6 and E7 proteins of the HPV16 virus to emulate loss of p53 and inactivation of the Rb pathway, respectively. Given the frequent activation of KRAS (>90% PDAC tumors) and its early role in p...
ORGANISM(S): Homo sapiens 
2016-01-19 | E-GEOD-58055 | biostudies-arrayexpress
TranscriptomicsBreast, colon, glioblastoma, lung, melanoma, ovarian, pancreas, prostate tumors and cell lines.
DNA copy number profiling for all primary tumor samples and cell lines was performed by ROMA, a form of comparative genomic hybridization. The aim was to identify commonly amplifiied and deleted regions. 538 primary tumor samples and 253 human cell lines were analyzed.
ORGANISM(S): Homo sapiens 
2011-08-23 | E-GEOD-31586 | biostudies-arrayexpress
TranscriptomicsHepatocellular carcinoma (HCC) tumors and cell lines
DNA copy number profiling for all primary tumor samples and HCC cell lines was performed by ROMA, a form of comparative genomic hybridization. The aim was to identify commonly amplifiied and deleted regions across human HCC. 88 primary HCC samples and 12 human HCC cell lines were analyzed.
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-22916 | biostudies-arrayexpress
TranscriptomicsExpression data from postnatal mouse brain regions of Ts1Cje and disomic C57BL/6 mice.
The Ts1Cje mouse model of Down syndrome (DS) has partial triplication of mouse chromosome 16 (MMU16), which is partially homologous to human chromosome 21. The mouse model develops various neuropathological features identified in DS individuals. We analysed the effect of partial triplication of the ...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-49050 | biostudies-arrayexpress
UnknownCost-Effectiveness of Treatments after Closed Extraarticular Distal Radius Fractures in Older Adults from the WRIST Clinical Trial.
Not available
S-EPMC7855198 | biostudies-literature
GenomicsAcquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes

We performed genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult patients with de novo AML using the Affymetrix Genome-Wide Human SNP array 6.0 containing 1.85 million features. Acquired copy number alterations (CNA) were confirmed using an independent, hig...

phs000201.v1.p1 | EGA
Genomics20181113_EGA_MELA_Naevus - samples
Aligned, merged and deduplicated BAM files from HiSeq whole genome sequencing of 28 samples: matched tumour-normal pairs from 14 melanocytic nevi cases
EGAD00001004474 | EGA
Genomics20191008_EGA_MELA_Acral - samples
Illumina platform sequencing of whole genome libraries prepared from paired tumour/normal samples from 87 cases of melanoma Acral subtype. 63 cases also have RNASeq sequencing from the tumour sample.
EGAD00001005500 | EGA
Genomics20190219_EGA_MelanomaOnTreatment - samples
Illumina platform sequencing data for matched tumour-normal DNA samples from 77 melanoma patients participating in a study investigating response to immunotherapy. Selected cases also have RNA sequencing of the tumour.
EGAD00001004869 | EGA
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