Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...
This is a case-control study of alcoholism, in which the subjects have been drawn from the Collaborative Study on the
Genetics of Alcoholism (COGA), a large, ongoing family-based study that includes subjects from seven sites around the US.
COGA has gathered detailed, standardized data on ...
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell line...
