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GenomicsSox2 ChIP-seq in hindbrain and spinal cord neural progenitors differentiated from mouse embryonic stem cells
Sox2 is a key determinant of neural cell identity, expressed in neural progenitors from anterior to posterior levels. We asked if the occupancy of this factor changes in neural progenitors with different axial identities. To this end, we performed the directed differentiation of mouse embryonic stem...
ORGANISM(S): Mus musculus 
2018-08-27 | E-MTAB-6348 | biostudies-arrayexpress
TranscriptomicsATAC-seq on ESCs undergoing directed differentiation towards defined neural fates
We have used ATAC-seq to track cell state changes that occur during the differentiation of mouse embryonic stem cells to defined neural progenitor fates. We have performed ATAC-seq every 24 hours in cells en route to 3 distinct neural progenitors fates, anterior, hindbrain and spinal cord. This has ...
ORGANISM(S): Mus musculus 
2018-08-27 | E-MTAB-6337 | biostudies-arrayexpress
ProteomicsConvergence of SIRT1 and ATR signaling to modulate replication origin dormancy
SIRT1 chromatin interactome analysis was performed to identify SIRT1 molecular targets involved in replication initiation from cells containing either WT or H363Y SIRT1. Co-IP-MS of pT530 SIRT1 from chromatin extracts was performed. Files are: 1422 WT SIRT1 untreated U2OS; 1423 WT SIRT1 H2O2 treated...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088103 | MassIVE
ProteomicsStructure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism
Human cytomegalovirus (CMV) is a highly relevant pathogen, and its rodent counterparts serve as common infection models. Global proteome profiling of rat CMV (RCMV)-infected cells uncovered a pronounced loss of the transcription factor STAT2, which is crucial for interferon signalling. Deletion muta...
ORGANISM(S): Cellular Organisms 
2022-12-15 | PXD033366 | JPOST Repository
UnknownStratification and therapeutic potential of PML in metastatic breast cancer.
Not available
S-EPMC4999521 | biostudies-literature
MetabolomicsGNPS - NISTfecalRM_Astral_HypersilGoldC18_positive
NIST fecal reference material extracted with 50% MeOH and prepared in different dilutions and reconstitution solvents. The analysis was conducted using a Hypersil Gold (C18) in positive ionization mode on a Astral via different MS-modes (positive ionization mode).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-28 | MSV000093526 | GNPS
UnknownATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer
Not available
S-SCDT-10_15252-EMMM_202217313 | biostudies-other
TranscriptomicsGene expression data for worker honey bees experimentally exposed to a dual infection with Deformed wing virus and Nosema ceranae.
Bees from 3 unrelated colonies were injected with 1ul PBS extract containing 10^9 genome equivalent of Deformed wIng virus (DWV) and/or fed 10µl sucrose solution containing 10^5 fresh Nosema ceranae spores. Control bees were injected and fed with an equivalent DWV- and Nosema-free extract respectiv...
ORGANISM(S): Apis mellifera 
2017-03-08 | E-MTAB-5508 | biostudies-arrayexpress
UnknownSPEN haploinsufficiency causes a neurodevelopmental disorder overlapping proximal 1p36 deletion syndrome with an episignature of X chromosomes in females.
Not available
S-EPMC8008487 | biostudies-literature
UnknownImproving care at scale: process evaluation of a multi-component quality improvement intervention to reduce mortality after emergency abdominal surgery (EPOCH trial).
Not available
S-EPMC6233578 | biostudies-literature
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