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TranscriptomicsImportant role for secretoglobin(SCGB)3A2 in lung development
Secretoglobin (SCGB) 3A2 was originally identified as a downstream target in lung for the homeodomain transcription factor NKX2-1, whose null mutation resulted in severely hypoplastic lungs. A very low level of SCGB3A2 is expressed in lungs at embryonic day (E) 11.5 during mouse development, which...
ORGANISM(S): Mus musculus 
2009-12-25 | E-GEOD-11226 | biostudies-arrayexpress
TranscriptomicsSCGB3A2 suppresses bleomycin-induced pulmonary fibrosis through activation of STAT1 and up-regulation of SMAD7
We report for the first time that secretoglobin (SCGB) 3A2, a novel cytokine-like molecule, predominantly expressed in pulmonary airways epithelium, drastically reduced the severity of lung fibrosis using bleomycin-induced mouse model. DNA microarrays were performed using RNAs isolated from mouse lu...
ORGANISM(S): Mus musculus 
2011-04-30 | E-GEOD-21560 | biostudies-arrayexpress
TranscriptomicsGene expression of mice over-expressing secretoglobin 3A2 in lung
Secretoglobin (SCGB) 3A2 is a cytokine-like secretory protein and is predominantly expressed in airway epithelial cells. While SCGB3A2 is known to have anti-inflammatory, growth factor, and anti-fibrotic activities, its roles in lung homeostasis and diseases are still elusive. In order to obtain an ...
ORGANISM(S): Mus musculus 
2015-12-23 | GSE47931 | GEO
TranscriptomicsImportant role for secretoglobin(SCGB)3A2 in lung development
Secretoglobin (SCGB) 3A2 was originally identified as a downstream target in lung for the homeodomain transcription factor NKX2-1, whose null mutation resulted in severely hypoplastic lungs. A very low level of SCGB3A2 is expressed in lungs at embryonic day (E) 11.5 during mouse development, which m...
ORGANISM(S): Mus musculus 
2009-12-26 | GSE11226 | GEO
UnknownMammalian derived lipocalin and secretoglobin respiratory allergens strongly bind ligands with potentially immune modulating properties.
Not available
S-EPMC9385959 | biostudies-literature
UnknownEmerging role of an immunomodulatory protein secretoglobin 3A2 in human diseases.
Not available
S-EPMC9271138 | biostudies-literature
UnknownOncostatin M regulates secretoglobin 3A1 and 3A2 expression in a bidirectional manner.
Not available
S-EPMC2677441 | biostudies-literature
UnknownLung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation and Immunity.
Not available
S-EPMC7558713 | biostudies-literature
UnknownSecretoglobin 3A2 peptides have therapeutic potential for allergic airway inflammation.
Not available
S-EPMC11631205 | biostudies-literature
UnknownSecretoglobin 3A2 protects lung from developing cigarette smoke-induced pulmonary emphysema.
Not available
S-EPMC10118454 | biostudies-literature
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