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TranscriptomicsSpatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
Protein synthesis and autophagic degradation are regulated in an opposite manner by mammalian target of rapamycin (mTOR), whereas under certain conditions it would be beneficial if they occured in unison to handle rapid protein turnover. We observed a distinct cellular compartment at the trans-side ...
ORGANISM(S): Homo sapiens 
2011-05-04 | E-GEOD-28464 | biostudies-arrayexpress
TranscriptomicsDepletion of HPV16 oncogenes induces autophagy and senescence in a cervical carcinogenesis model, irrespective of viral physical state
We utilised our in vitro model of cervical neoplastic progression, W12, to investigate the effect of HPV16 viral oncogene depletion on well-defined integrant- and episome- associated series. To target HPV16 viral oncogenes we used our previously published E7-targeting siRNA sequence that caused subs...
ORGANISM(S): Homo sapiens 
2013-08-12 | E-MTAB-1331 | biostudies-arrayexpress
ProteomicsStress enhances secretory autophagy increasing extracellular Bdnf maturation
Stress response is a fundamental mechanism to maintain a healthy homeostasis and its disruption is implicated in several psychiatric disorders. Autophagy is one of the mechanisms regulating homeostasis, and it is known to be activated by cellular stressors such as starvation. In a previous study, w...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-05 | PXD017076 | Pride
Secretory autophagy Stress Secretome 
UnknownSecretory autophagy during lysosome inhibition (SALI).
Not available
S-EPMC9542525 | biostudies-literature
GenomicsPlekhg5 regulates the unconventional secretion of Sod1 by presynaptic secretory autophagy
Plekhg5 regulates the unconventional secretion of Sod1 by presynaptic secretory autophagy
PRJNA1122581 | ENA
GenomicsSKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration
SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration
PRJNA751049 | ENA
UnknownSecretory autophagy machinery and vesicular trafficking are involved in HMGB1 secretion.
Not available
S-EPMC8496717 | biostudies-literature
Unknown6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
Not available
S-EPMC6152502 | biostudies-literature
ProteomicsSecretory autophagy mediates mitochondria clearance in the absence of the mATG8-conjugation machinery
PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents an important mechanism in mitochondrial quality control (MQC) via clearance of damaged mitochondria. Although it is well known that the conjugation of mammalian ATG8s to phosphatidylethanolamine (PE) is a key step in autophag...
ORGANISM(S): Homo sapiens (Human) 
2022-06-03 | PXD025356 | Pride
Mitochondria Autophagy 
UnknownInsulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease.
Not available
S-EPMC4854558 | biostudies-literature
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