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TranscriptomicsHmga2 is required for canonical WNT signaling during lung development
The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. Here we deciphered the role of the high mobility group AT-hook protein 2 (HMGA2) during lung development by analyzing the lung of Hmga2 deficient mice (Hmga2-/-).We found that Hmga2 is expressed i...
ORGANISM(S): Mus musculus 
2014-03-07 | E-GEOD-55340 | biostudies-arrayexpress
TranscriptomicsIdentification of right heart-enriched genes in a murine model of chronic outflow tract obstruction
The right ventricle (RV) differs in several aspects from the left ventricle (LV) including its embryonic origin, physiological role and anatomical design. In contrast to LV hypertrophy, little is known about the molecular circuits, which are activated upon RV hypertrophy (RVH). We established a high...
ORGANISM(S): Mus musculus 
2011-07-07 | E-GEOD-30428 | biostudies-arrayexpress
TranscriptomicsIl13-stimulation of human paSMCs
Idiopathic pulmonary arterial hypertension (IPAH) is characterized by medial hypertrophy due to pulmonary arterial smooth muscle cell (paSMC) hyperplasia. Interleukin (IL)-13 is a potent regulator of tissue fibrosis and remodelling, and its effects are dependent on the cell-type specific expression ...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-15739 | biostudies-arrayexpress
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