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TranscriptomicsTumor gene expression analysis - PI3K Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma
Of the 142 patients enrolled in Study CHRONOS-1, an open-label, single-arm, Phase II study evaluating the efficacy and safety of single-agent copanlisib in patients with relapsed or refractory, indolent B-cell lymphoma (NCT01660451; Part B), 96 archival formalin-fixed paraffin-embedded tumor tissues...
ORGANISM(S): Homo sapiens 
2017-12-01 | E-MTAB-6088 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from wild type and ESR1 mutant mice (EAAE/EAAE) after treatment with ethinylestradiol versus vehicle
To understand the contribution of direct versus indirect DNA binding of estrogen-activated ERa and ERa(EAAE/EAAE) on gene expression in the murine liver, RNA was isolated from the liver of wild-type and ERa(EAAE/EAAE) mice treated perorally with 100µg/kg ethinylestradiol(EE) or vehicle for 4 or 24 h...
ORGANISM(S): Mus musculus 
2010-01-28 | E-TABM-739 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of xenografted tumors derived from human ovarian cell line model A2780 and its cisplatin resistant variant A2780cis
Molecular mechanisms underlying the development of resistance to platinum treatment in patients with ovarian cancer remain poorly understood. This is mainly due to the lack of appropriate in vivo models allowing identification of factors that are regulated during initial treatment and of acquired re...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-MTAB-1858 | biostudies-arrayexpress
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