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ProteomicsProteomic analysis of glomeruli from Thsd7a podocyte knockout and WT mice
Proteomics experiment 1/3 associated with this work. THSD7A is a key podocyte antigen in membranous nephropathy (MN), an antibody-mediated autoimmune disease. While the pathogenic role of autoantibodies targeting THSD7A in MN is well described, the consequences of autoantibody binding for podocyte h...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-30 | PXD065322 | Pride
Podocyte injury Experimental membranous nephropathy Podocyte-specific knockout of thsd7a 
ProteomicsTHSD7A interactome in native mouse glomeruli
Proteomics experiment 2/3 associated with this work. THSD7A is a key podocyte antigen in membranous nephropathy (MN), an antibody-mediated autoimmune disease. While the pathogenic role of autoantibodies targeting THSD7A in MN is well described, the consequences of autoantibody binding for podocyte h...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-30 | PXD065323 | Pride
Ap-ms Interactome of thsd7a Podocyte injury Co-ip Experimental membranous nephropathy 
ProteomicsDeficiency of THSD7A reverses glomerular proteomic profiles in anti-THSD7A antibody induced membranous nephropathy models
Proteomics experiment 3/3 associated with this work. THSD7A is a key podocyte antigen in membranous nephropathy (MN), an antibody-mediated autoimmune disease. While the pathogenic role of autoantibodies targeting THSD7A in MN is well described, the consequences of autoantibody binding for podocyte h...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-30 | PXD065344 | Pride
Anti-thsd7a antibody induced membranous nephropathy Podocyte injury Experimental membranous nephropathy 
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 1/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): Homo sapiens (Human) 
2025-02-26 | PXD036658 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 3/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): Homo sapiens (Human) 
2025-02-26 | PXD036661 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 4/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-02-26 | PXD036662 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 5/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): synthetic construct 
2025-02-26 | PXD036666 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
ProteomicsFlycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 6/6
During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide ba...
ORGANISM(S): Mus musculus (Mouse) synthetic construct 
2025-02-26 | PXD036668 | Pride
Drug development Antibodies Peptide barcodes Cassette dosing 
UnknownIMA Genome-F 5: Draft genome sequences of Ceratocystis eucalypticola, Chrysoporthe cubensis, C. deuterocubensis, Davidsoniella virescens, Fusarium temperatum,Graphilbum fragrans, Penicillium nordicum, and Thielaviopsis musarum.
Not available
S-EPMC4681265 | biostudies-literature
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