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TranscriptomicsGlucocorticoid and androgen receptor profiling (ChIP-seq) in U2OS-GR and U2OS-AR cells upon hormone treatment
We performed ChIP-seq targeting the glucocorticoid receptor (GR) in the U2OS-GR cell line and the androgen receptor (AR) in the U2OS-AR cell line. The cell lines are derived from U2OS ATTC:HTB-96 and stably transfected with an expression construct for either rat GR or human AR, respectively. The U2O...
ORGANISM(S): Homo sapiens 
2021-03-09 | E-MTAB-9616 | biostudies-arrayexpress
ProteomicsThe Trypanosoma cruzi Antigen and Epitope Atlas: discovery of antibody specificities in human Chagas Disease patients across human populations
These assays represent an antigen discovery screening, and epitope mapping characterization. In this screening two complete proteomes from Trypanosoma cruzi, from two different strains (CL-Brener, Sylvio X10), were displayed in the form of short peptides (tiling array, overlapped) and assayed with p...
ORGANISM(S): Homo sapiens 
2022-08-20 | E-MTAB-11651 | biostudies-arrayexpress
TranscriptomicsChIP-chip mapping of RNA polymerase II binding in D.melanogaster stage 5 embryos
ChIP-chip was performed using chromatin isolated from formaldehyde crosslinked, stage 5 embryos, and 8WG16 monoclonal antibody against RNA polymerase II(Covance Inc.). The chromatin immunoprecitation and hybridization for each antibody were carried out in duplicates, and in each chromatin immunopr...
ORGANISM(S): Drosophila melanogaster 
2011-02-28 | E-TABM-1130 | biostudies-arrayexpress
ProteomicsThe Trypanosoma cruzi Antigen and Epitope Atlas: fine characterization of antibody specificities in human Chagas Disease patients across human populations
These assays represent antibody-binding assays to analyze seroprevalence of antigens and epitopes at the individual level and also to perform fine epitope mapping characterizations. In this screening 392,299 peptides derived from reactive (antigenic) regions of Trypanosoma cruzi proteins were displa...
ORGANISM(S): Homo sapiens 
2022-08-20 | E-MTAB-11655 | biostudies-arrayexpress
TranscriptomicsCooperative binding of DNA sequence non-specific HMGbox Factor Ubf and TBP-TAF complex SL1 determines RNA Polymerase I promoter recognition in vivo and its dysfunction underlies the Ubf-E210K neuroregression syndrome
Transcription of the >200 rRNA genes (rDNA) by RNA Polymerase I (RPI) determines as much as 35% of total nuclear RNA synthesis and is a major determinant of cell growth implicated in a range of hypertrophic and developmental disorders. Activation of the rDNA involves the formation of an extended nuc...
ORGANISM(S): Mus musculus 
2021-08-31 | E-MTAB-10433 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of sperm extracted from the epididymis in naked mole-rat subordinates, naked mole-rat ex-subordinates, and mice
Naked mole-rat show a strong phenotype of sperm hypo-motility and abnormal morphology. Comparative genomic analyses in our study presenting the telomere-to-telomere genome for the naked mole-rat identified several sperm-gene relaxation and sperm-gene loss events in the NMR. To test the transcriptomi...
ORGANISM(S): Mus musculus 
2026-07-31 | E-MTAB-17270 | biostudies-arrayexpress
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