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MetabolomicsSelective profiling of translationally active tRNAs and their dynamics under stress

During translation, transfer RNAs (tRNAs) deliver specific amino acids to the ribosome in a coordinated manner with the sequence encoded by the mRNA. Despite their central role in protein synthesis, the precise contribution of tRNAs to the modulation of translation remains poorly understood, prim...

2026-06-25 | MTBLS12806 | MetaboLights
TranscriptomicsSelective ribosome profiling reveals the co-translational chaperone action of trigger factor in vivo
As nascent polypeptides exit ribosomes, they are engaged by a series of processing, targeting and folding factors. Here we present a selective ribosome profiling strategy that enables global monitoring of when these factors engage polypeptides in the complex cellular environment. Studies of the Esch...
ORGANISM(S): Escherichia coli 
2011-12-09 | E-GEOD-33671 | biostudies-arrayexpress
GenomicsEbp1-selective ribosome profiling analysis of Neuro2a cells with Ebp1-immuno-precipitation
Ebp1-selective ribosome profiling analysis of Neuro2a cells with Ebp1-immuno-precipitation
PRJNA661060 | ENA
GenomicsPrinciples of cotranslational mitochondrial protein import revealed by selective ribosome profiling
Principles of cotranslational mitochondrial protein import revealed by selective ribosome profiling
PRJNA1076084 | ENA
GenomicsSelective ribosome profiling of the DHX29-bound ribosomes in HEK293T cells
Selective ribosome profiling of the DHX29-bound ribosomes in HEK293T cells
PRJNA1105347 | ENA
GenomicsSelective ribosome profiling to study interactions of translating ribosomes in yeast
Selective ribosome profiling to study interactions of translating ribosomes in yeast
PRJNA507750 | ENA
GenomicsRibosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors
Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors
PRJNA434112 | ENA
TranscriptomicsTranscriptome-wide identification of LIN28A targets in mouse embryonic stem cell (A3-1) [Illumina Seq]
LIN28A is a highly-conserved RNA-binding protein which is known to be involved in embryonic development, stem cell maintenance and proliferation. LIN28A is expressed in various types of cancer, and they are associated with advanced tumor malignancy. In embryonic stem cell, LIN28A specifically binds ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-37111 | biostudies-arrayexpress
TranscriptomicsmRNA Poly(A)-tail Changes Specified by Deadenylation Broadly Reshape Translation in Drosophila Oocytes and Early Embryos
Because maturing oocytes and early embryos lack transcription, posttranscriptional regulatory processes must control their development. To better understand this control, we profiled translational efficiencies and poly(A)-tail lengths throughout Drosophila oocyte maturation and early embryonic deve...
ORGANISM(S): Drosophila melanogaster 
2016-08-08 | E-GEOD-83616 | biostudies-arrayexpress
TranscriptomicsTranslational profiling in the unfolded protein response
The unfolded protein response (UPR) couples cellular translation rates and gene expression to the protein folding status of the endoplasmic reticulum (ER). Upon activation, the UPR machinery elicits a general suppression of protein synthesis and activation of stress gene expression, which act coordi...
ORGANISM(S): Mus musculus 
2014-08-28 | E-GEOD-53743 | biostudies-arrayexpress
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