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MetabolomicsSelective profiling of translationally active tRNAs and their dynamics under stress

During translation, transfer RNAs (tRNAs) deliver specific amino acids to the ribosome in a coordinated manner with the sequence encoded by the mRNA. Despite their central role in protein synthesis, the precise contribution of tRNAs to the modulation of translation remains poorly understood, prim...

2026-06-25 | MTBLS12806 | MetaboLights
TranscriptomicsSelective ribosome profiling reveals the co-translational chaperone action of trigger factor in vivo
As nascent polypeptides exit ribosomes, they are engaged by a series of processing, targeting and folding factors. Here we present a selective ribosome profiling strategy that enables global monitoring of when these factors engage polypeptides in the complex cellular environment. Studies of the Esch...
ORGANISM(S): Escherichia coli 
2011-12-09 | E-GEOD-33671 | biostudies-arrayexpress
GenomicsSelective ribosome profiling to study interactions of translating ribosomes in yeast
Selective ribosome profiling to study interactions of translating ribosomes in yeast
PRJNA507750 | ENA
GenomicsSelective 40S footprinting reveals that scanning ribosomes remain cap-tethered in human cells
Selective 40S footprinting reveals that scanning ribosomes remain cap-tethered in human cells
PRJNA579539 | ENA
GenomicsSpecific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes (Ribo-seq)
Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes (Ribo-seq)
PRJNA1116213 | ENA
GenomicsSelective ribosome profiling of the DHX29-bound ribosomes in HEK293T cells
Selective ribosome profiling of the DHX29-bound ribosomes in HEK293T cells
PRJNA1105347 | ENA
TranscriptomicsSelective 40S footprinting reveals that scanning ribosomes remain cap-tethered in human cells
Translation regulation occurs largely during initiation. Currently, translation initiation can be studied in vitro, but these systems lack features present in vivo and on endogenous mRNAs. Here we develop selective 40S footprinting for visualizing initiating 40S ribosomes on endogenous mRNAs in vivo...
ORGANISM(S): Mus musculus Homo sapiens 
2020-06-25 | GSE139391 | GEO
UnknownSelective ribosome profiling to study interactions of translating ribosomes in yeast.
Not available
S-EPMC7115923 | biostudies-literature
OtherSelective ribosome profiling to study interactions of translating ribosomes in yeast
A number of enzymes, targeting factors and chaperones engage ribosomes to support fundamental steps of nascent protein maturation, including enzymatic processing, membrane targeting and co-translational folding. The selective ribosome profiling (SeRP) method is a new tool for studying the co-transla...
ORGANISM(S): Saccharomyces cerevisiae 
2019-07-10 | GSE123166 | GEO
GenomicsSpecific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes (SLAM-Seq)
Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes (SLAM-Seq)
PRJNA1116215 | ENA
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