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GenomicsTranscriptional Regulation of the GPX1 Gene by TFAP2C and Aberrant CpG Methylation in Human Breast Cancer
The complexity of gene regulation has created obstacles to defining mechanisms that establish the patterns of gene expression characteristic of the different clinical phenotypes of breast cancer. Transcription factor TFAP2C plays a critical role in the regulation of both estrogen receptor-alpha (ERM...
ORGANISM(S): Homo sapiens 
2012-09-12 | E-GEOD-36351 | biostudies-arrayexpress
UnknownPlatyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione.
Not available
S-EPMC2440607 | biostudies-literature
TranscriptomicsPathways leading to phosphorylation of p450c17 and to the post-translational regulation of androgen biosynthesis
Cytochrome P450c17 (P450c17) is the single enzyme that catalyzes steroid 17alpha-hydroxylase and 17,20 lyase activities and hence is the crucial decision-making step that determines the class of steroid made in a steroidogenic cell. Although both activities are catalyzed on a single active site, the...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-44311 | biostudies-arrayexpress
TranscriptomicsUnderstanding toxicity pathways of gold nanoparticles: RNA expression study on Caco-2 human colon carcinoma cells
A safer design and higher eficacy of nano-gold therapeutic formulations requires examination of cellular responses to gold nanoparticles (AuNPs). In this work we compared cellular uptake, cytotoxicity and RNA expression patterns induced in Caco-2 cells of citrate-stabilized Au NP of two different si...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-55349 | biostudies-arrayexpress
UnknownMitochondria-Mediated Protein Regulation Mechanism of Polymorphs-Dependent Inhibition of Nanoselenium on Cancer Cells.
Not available
S-EPMC4981849 | biostudies-literature
TranscriptomicsSep15 and TR1 pathways in colon cancer promotion
Selenoproteins mediate the cancer-preventive properties of the essential nutrient selenium, but also have cancer-promoting effects. We examined the contributions of the 15-kDa selenoprotein (Sep15) and thioredoxin reductase 1 (TR1) to cancer development. Targeted down-regulation of either gene inhib...
ORGANISM(S): Mus musculus 
2016-02-01 | GSE55488 | GEO
UnknownMechanism of Ca2+-Dependent Pro-Apoptotic Action of Selenium Nanoparticles, Mediated by Activation of Cx43 Hemichannels.
Not available
S-EPMC8389560 | biostudies-literature
UnknownSelenomethionine regulation of p53 by a ref1-dependent redox mechanism.
Not available
S-EPMC137920 | biostudies-literature
TranscriptomicsDeficiency in the 15 kDa Selenoprotein Inhibits Tumorigenicity and Metastasis of Colon Cancer Cells
Selenium has cancer preventive activity that is mediated, in part, through selenoproteins. The role of the 15 kDa selenoprotein (Sep15) in colon cancer was assessed by preparing and using mouse colon CT26 cells stably transfected with shRNA constructs targeting Sep15. Metabolic 75Se-labeling and Nor...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-20390 | biostudies-arrayexpress
UnknownSelenium and its supplementation in cardiovascular disease--what do we know?
Not available
S-EPMC4446741 | biostudies-literature
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