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TranscriptomicsThe effects of dietary selenium on selenocysteine incorporation and selenoprotein expression
The goal of this study was to determine the effects of dietary selenium levels on translational control of selenoprotein synthesis in mouse liver. Wild type mice and mice expressing a mutant Sec-tRNA gene (TrspA37G) were fed diets supplemented with 0, 0.1, or 2 ppm selenium for 6 weeks. Livers were ...
ORGANISM(S): Mus musculus 
2013-09-17 | E-GEOD-46038 | biostudies-arrayexpress
TranscriptomicsDeficiency in the 15 kDa Selenoprotein Inhibits Tumorigenicity and Metastasis of Colon Cancer Cells
Selenium has cancer preventive activity that is mediated, in part, through selenoproteins. The role of the 15 kDa selenoprotein (Sep15) in colon cancer was assessed by preparing and using mouse colon CT26 cells stably transfected with shRNA constructs targeting Sep15. Metabolic 75Se-labeling and Nor...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-20390 | biostudies-arrayexpress
TranscriptomicsWild type mice (Trsp) vs Trsp-knockout mice (DTrsp) or A34 or G37L or G37H transgenic mice
Comparative analysis of gene expression in the liver of the Trsp-knockout mice (Trspfl/fl-AlbCre+/+) and A34 (Trspfl/fl-AlbCre+/+-A34t/t), G37L (Trspfl/fl-AlbCre+/+-G37t/t; 2 copies), G37H (Trspfl/fl-AlbCre+/+-G37t/t; 16 copies) transgenic mice with gene expression of wild type mice (Trsp+/+-AlbCre...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-12495 | biostudies-arrayexpress
TranscriptomicsKnockout of the selenocysteine tRNA (Trsp) gene in mouse macrophage
Comparative analysis of gene expression in bone marrow-derived macrophages (BMDM) from trsp knockout mice (Trspfl/fl-LysM-Cre+/-) and Control (Trspfl/fl-LysM-Cre-/-) mice. Selenium, a micronutrient whose deficiency in the diet causes immune dysfunction and inflammatory disorders, exerts its physio...
ORGANISM(S): Mus musculus 
2009-12-21 | E-GEOD-15610 | biostudies-arrayexpress
ProteomicsHepatic proteomic analysis of selenoprotein T knockout mice by TMT: Implications for the role of selenoprotein T in glucose and lipid metabolism
Selenoprotein T (SELENOT, SelT), a thioredoxin-like enzyme, exerts an essential oxidoreductase activity in the endoplasmic reticulum. However, its precise function remains unknown. To gain more understanding of SELENOT function, a conventional SELENOT knockout (KO) mouse model was constructed for th...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD023261 | Pride
Selenoprotein t  knockout  proteomics  tmt  glucose and lipid metabolism 
ProteomicsCopper impairs hepatic selenoprotein P release
Selenoprotein P is a hepatokine which is essential for maintaining systemic selenium homeostasis and is used as serum biomarker for the selenium status in humans. In addition to selenium, also copper homeostasis is mainly regulated by the liver coordinating systemic distribution of copper bound to c...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD036300 | Pride
Selenoprotein p Wilson’s disease Selenium Copper Secretome 
ProteomicsParacrine secretion of monounsaturated fatty acids prevents ferroptosis in triple negative breast cancer and reveals selenocysteine synthesis dependency for metastatic seeding.
The limited availability of therapeutic options for patients with triple-negative breast cancer (TNBC) contributes to the high rate of metastatic recurrence and poor prognosis. Ferroptosis is a cell death caused by iron-dependent lipid peroxidation counteracted by the antioxidant activity of selenop...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-17 | MSV000094784 | MassIVE
TranscriptomicsHypermethylated capped selenoprotein mRNAs in mammals
Mammalian mRNAs are generated by complex and coordinated biogenesis pathways and acquire 5'-end m7G caps that play fundamental roles in processing and translation. Here we show that several selenoprotein mRNAs are not recognized efficiently by translation initiation factor eIF4E because they bear a ...
ORGANISM(S): Homo sapiens 
2014-05-14 | GSE57625 | GEO
TranscriptomicsHypermethylated capped selenoprotein mRNAs in mammals
Mammalian mRNAs are generated by complex and coordinated biogenesis pathways and acquire 5'-end m7G caps that play fundamental roles in processing and translation. Here we show that several selenoprotein mRNAs are not recognized efficiently by translation initiation factor eIF4E because they bear a ...
ORGANISM(S): Homo sapiens 
2014-05-14 | E-GEOD-57625 | biostudies-arrayexpress
ProteomicsSelenoprotein S plays role in translation and membrane protein biogenesis
Human selenoprotein S (selenos) is part of the integrated cellular stress response and linked to protein quality control and signaling pathways. Consequently, genetic polymorphisms of selenos are associated with increased risk for diabetes, dyslipidemia, and cardiovascular diseases. Determining the ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD075535 | Pride
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