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ProteomicsHepatic proteomic analysis of selenoprotein T knockout mice by TMT: Implications for the role of selenoprotein T in glucose and lipid metabolism
Selenoprotein T (SELENOT, SelT), a thioredoxin-like enzyme, exerts an essential oxidoreductase activity in the endoplasmic reticulum. However, its precise function remains unknown. To gain more understanding of SELENOT function, a conventional SELENOT knockout (KO) mouse model was constructed for th...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD023261 | Pride
Selenoprotein t  knockout  proteomics  tmt  glucose and lipid metabolism 
TranscriptomicsWild type mice (Trsp) vs Trsp-knockout mice (DTrsp) or A34 or G37L or G37H transgenic mice
Comparative analysis of gene expression in the liver of the Trsp-knockout mice (Trspfl/fl-AlbCre+/+) and A34 (Trspfl/fl-AlbCre+/+-A34t/t), G37L (Trspfl/fl-AlbCre+/+-G37t/t; 2 copies), G37H (Trspfl/fl-AlbCre+/+-G37t/t; 16 copies) transgenic mice with gene expression of wild type mice (Trsp+/+-AlbCre...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-12495 | biostudies-arrayexpress
TranscriptomicsKnockout of the selenocysteine tRNA (Trsp) gene in mouse macrophage
Comparative analysis of gene expression in bone marrow-derived macrophages (BMDM) from trsp knockout mice (Trspfl/fl-LysM-Cre+/-) and Control (Trspfl/fl-LysM-Cre-/-) mice. Selenium, a micronutrient whose deficiency in the diet causes immune dysfunction and inflammatory disorders, exerts its physio...
ORGANISM(S): Mus musculus 
2009-12-21 | E-GEOD-15610 | biostudies-arrayexpress
UnknownSelenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells.
Not available
S-EPMC3471091 | biostudies-literature
ProteomicsCopper impairs hepatic selenoprotein P release
Selenoprotein P is a hepatokine which is essential for maintaining systemic selenium homeostasis and is used as serum biomarker for the selenium status in humans. In addition to selenium, also copper homeostasis is mainly regulated by the liver coordinating systemic distribution of copper bound to c...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD036300 | Pride
Selenoprotein p Wilson’s disease Selenium Copper Secretome 
ProteomicsParacrine secretion of monounsaturated fatty acids prevents ferroptosis in triple negative breast cancer and reveals selenocysteine synthesis dependency for metastatic seeding.
The limited availability of therapeutic options for patients with triple-negative breast cancer (TNBC) contributes to the high rate of metastatic recurrence and poor prognosis. Ferroptosis is a cell death caused by iron-dependent lipid peroxidation counteracted by the antioxidant activity of selenop...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-17 | MSV000094784 | MassIVE
UnknownHepatic Proteomic Analysis of Selenoprotein T Knockout Mice by TMT: Implications for the Role of Selenoprotein T in Glucose and Lipid Metabolism.
Not available
S-EPMC8395235 | biostudies-literature
UnknownThe Selenoprotein MsrB1 Instructs Dendritic Cells to Induce T-Helper 1 Immune Responses.
Not available
S-EPMC7589095 | biostudies-literature
TranscriptomicsSelT knockdown mouse fibroblast cells vs control cells
Analysis of gene expression in NIH 3T3 cells stably knockdown for Selt (GenBank accession number NM_001040396) using vector based siRNA technique in comparison to gene expression of vector transfected NIH 3T3 cells. siSelT-1 construct (spanning nucleotides 205-224 of Selt, GenBank accession number N...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-17087 | biostudies-arrayexpress
UnknownSelenoprotein biosynthesis defect causes progressive encephalopathy with elevated lactate.
Not available
S-EPMC4520820 | biostudies-literature
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