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TranscriptomicsEffect of a dual specificity PI3K/mTOR inhibitor, NVP-BEZ235, on human ovarian cancer cell lines grown in 3D culture
Analysis of the effects of a dual specificity PI3K/mTOR inhibitor on two human ovarian cell lines, OV2008 and MCAS. Results provide insight into the adaptive response to PI3K/mTOR inhibition in matrix attached ovarian cancer cells. The PI3K/mTOR-pathway is the most commonly deregulated pathway in e...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-GEOD-28992 | biostudies-arrayexpress
TranscriptomicsGene expression profiles induced by shRNA-mediated knockdown of PDEF in MCF7 mammary epithelial cell line
Microarray gene expression analysis was performed in MCF7 cells transduced with a non-specific shRNA or PDEF-targeting shRNA, and both subjected to hormone depletion for 48 hours. Analyses of differentially expressed genes combined with gene ontology revealed a downregulation of cell cycle related-g...
ORGANISM(S): Homo sapiens 
2014-03-29 | E-GEOD-40985 | biostudies-arrayexpress
TranscriptomicsPDEF knockdown and overexpression in mammary epithelial cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-03-29 | E-GEOD-40987 | biostudies-arrayexpress
TranscriptomicsGene expression profiles induced by overexpression of PDEF in MCF10A mammary epithelial cell line
Recent studies suggest that PDEF is required for secretory cell differentiation in several epithelial tissues. To investigate PDEF in the mammary gland, we examined the effect of this transcription factor on gene expression using microarray based profiling of MCF-10A cells. These cells are non-trans...
ORGANISM(S): Homo sapiens 
2014-03-29 | E-GEOD-40986 | biostudies-arrayexpress
TranscriptomicsGene profiles induced by overexpression of wild-type and mutant Notch1 variants in MCF10A mammary epithelial cell line
Expression of a constitutively active Notch-1 intracellular domain (NICD) in MCF-10A cells was found to induce two distinct types of 3D structures: large, hyperproliferative structures and small, growth-arrested structures with reduced cell-to-matrix adhesion. These heterogeneous phenotypes reflect...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20285 | biostudies-arrayexpress
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