Sort   by:  
 Page size 
TranscriptomicsThe Polycomb Group Protein Bmi-1 is essential for the growth of Multiple Myeloma cells
The RPMI-8226 human multiple myeloma cell line was stably infected with either a validated shRNA against BMI1 or a control shRNA. RNA was prepared from these lines, +/- doxycycline induction and at various time points post-induction. Samples were hybridized on the Affymetrix U133plus2 human genome...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-21912 | biostudies-arrayexpress
UnknownRequirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer.
Not available
S-EPMC12223508 | biostudies-literature
UnknownModeling genomic diversity and tumor dependency in malignant melanoma.
Not available
S-EPMC10493008 | biostudies-literature
TranscriptomicsIntegrated genomic profiling of endometrial carcinoma
Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation Although 75% of endometrial cancers are treated at an early stage, 15% to 20% of these recur. We performed an integrated analysis of genome-wide expression and copy-number dat...
ORGANISM(S): Homo sapiens 
2009-03-23 | E-GEOD-14860 | biostudies-arrayexpress
UnknownAn antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin.
Not available
S-EPMC3924863 | biostudies-literature
TranscriptomicsComparison of gene expression alterations induced by distinct PI3K inhibitors
The goal is the characterization of the off-target activity of BKM120 observed in A2058 human melanoma cell line at IC90 concentration (3.606 µM) but not at lower concentrations. Controls are BEZ235, GDC0941, showing no off-target activity. A secondary objective is the characterizations of drug eff...
ORGANISM(S): Homo sapiens 
2012-06-30 | E-GEOD-33643 | biostudies-arrayexpress
TranscriptomicsSimilarity of PDXs between passages and lineages using Affymetrix mRNA expression data
PDX tumors at various passages post first implantation in nude mice PDX tumors were profiled at different passages when they reached ~400mm3
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-78806 | biostudies-arrayexpress
TranscriptomicsTargeting resistance to Smoothened antagonists by inhibiting the PI3K pathway
Mutations in Hedgehog (Hh) pathway genes, leading to constitutive activation of Smoothened (Smo), occur in sporadic medulloblastoma, the most common brain cancer in children. Antagonists of Smo induce tumor regression in mouse models of medulloblastoma and hold great promise for targeted therapy fo...
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-19657 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for soft tissue sarcoma samples
Soft tissue sarcomas are aggressive mesenchymal cancers that affect more than 10,600 new patients per year in the US, about 40% of whom will die of their disease. Soft tissue sarcomas exhibit remarkable histologic diversity, with more than 50 recognized subtypes, but our knowledge of their genomic a...
ORGANISM(S): Homo sapiens 
2010-07-05 | E-GEOD-21123 | biostudies-arrayexpress
TranscriptomicsWhole-transcript expression data for soft-tissue sarcoma tumors and control normal fat specimens
Soft tissue sarcomas are aggressive mesenchymal cancers that affect more than 10,600 new patients per year in the US, about 40% of whom will die of their disease. Soft tissue sarcomas exhibit remarkable histologic diversity, with more than 50 recognized subtypes, but our knowledge of their genomic a...
ORGANISM(S): Homo sapiens 
2010-07-05 | E-GEOD-21122 | biostudies-arrayexpress
Sort   by:  
 Page size