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TranscriptomicsMelanoma cell culture phenotypes
Recent trials with MAPK inhibitors have shown promising results in many patients with metastatic melanoma; however, nearly all responding patients experience disease relapse. We describe here how melanoma cells respond to MAPK inhibition in a phenotype-specific manner, suggesting that slow cycling i...
ORGANISM(S): Homo sapiens 
2011-04-05 | E-GEOD-28335 | biostudies-arrayexpress
TranscriptomicsEffects of depleting the Pkh activity in yeast.
The yeast proteins Pkh1 and Pkh2 are functional counterparts of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1). Cells carrying simultaneous deletion in both genes, PKH1 and PKH2 are not viable, at least in some genetic backgrounds (Casamayor et al., 1999; Inagaki et al., 1999). C...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-30 | E-GEOD-32623 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to heat shock in Pkh-depleted yeast cells.
The yeast proteins Pkh1 and Pkh2 are functional counterparts of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1). Cells carrying simultaneous deletion in both genes, PKH1 and PKH2 are not viable, at least in some genetic backgrounds (Casamayor et al., 1999; Inagaki et al., 1999). C...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-30 | E-GEOD-33904 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of yeast to determine size characteristics of yeast haploid deletion strains separated by elutriation
Determination of size characteristics of pools of yeast haploid deletion strains by elutriation and barcode analysis.
ORGANISM(S): Saccharomyces cerevisiae 
2008-02-15 | E-MEXP-1200 | biostudies-arrayexpress
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