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ProteomicsProteomics of the dentate gyrus reveals semantic dementia specific molecular pathology
Background Semantic dementia (SD) is a subtype of frontotemporal dementia (FTD) characterized by language deficits due to severe temporal lobe degeneration. The consistent neuropathological diagnosis is FTD-TDP subtype C, with characteristic round TDP-43 protein inclusions in the dentate gyrus. Desp...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD033060 | Pride
Semantic dementia Proteomics Mass spectrometry Frontotemporal dementia Tdp-43 
ProteomicsProteomics of the temporal cortex in Semantic Dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome
Semantic dementia (SD) is a clinical subtype of frontotemporal dementia characterized by impaired word comprehension and semantic memory, and occurs nearly always sporadically. Neuroimaging typically reveals asymmetric, predominantly left-sided, atrophy of the anterior temporal pole, anterior fusifo...
ORGANISM(S): Homo sapiens (Human) 
2026-01-16 | PXD062722 | Pride
Semantic dementia  ftld-tdp type c  temporal cortex  quantitative proteomics  rnp complex  presynaptic regulation calcium levels  tardbp-anxa11 interactome  immunohistochemistry 
TranscriptomicsInduced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
Multiple FTD patient-specific iPSC lines were generated for the first time, Human neurons of progranulin haploinsufficiency have been established. PGRN S116X neurons are more sensitive to kinase inhibitors-induced cell stress, which can be rescued by ectopic progranulin expression, revealing progran...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-40378 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation analysis identifies epigenetic differences in Alzheimer’s disease and frontotemporal dementia in brain tissue and lymphoblastoid cell lines
We have performed methylation microarray analysis of two types of dementia, Alzheimer's disease (AD) and frontotemporal dementia (FTD), using two kind of samples, frozen brain tissue and lymphoblastoid cell lines.
ORGANISM(S): Homo sapiens 
2024-01-01 | E-MTAB-11975 | biostudies-arrayexpress
ProteomicsPathogenic human tau in the Line 66 model of frontotemporal dementia
Transgenic human tau in subcellular fractions extracted after electrophoresis of L66 mouse brain extract. For higher sequence coverage trypsin (Tr) and thermolysin (TL) digests were analysed.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-08-13 | MSV000085945 | MassIVE
TranscriptomicsC9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD
Noncoding expansions of a hexanucleotide repeat (GGGGCC) in the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. Here we report transgenic mice carrying a bacterial artificial chromosome (BAC) containing the full human C9orf72 gene with ei...
ORGANISM(S): Mus musculus 
2016-02-10 | E-GEOD-77720 | biostudies-arrayexpress
TranscriptomicsTargeted degradation of sense and antisense C9orf72 RNA foci as therapy for amyotrophic lateral sclerosis and frontotemporal dementia (Multiplex Analysis of PolyA-linked Sequences)
Purpose: The purpose of this experiment is to identify a C9-ALS/FTD specific genomic profile in fibroblast lines that is distinct from sporadic ALS without C9orf72 expansion and non-neurologic control cells. The study will then evaluate the effect on this identified profile of ASO treatment targetin...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-51684 | biostudies-arrayexpress
UnknownSemantic variant primary progressive aphasia with ANXA11 p.D40G.
Not available
S-EPMC11881632 | biostudies-literature
TranscriptomicsMethylation state of human post-mortem brain tissue from the frontal lobe of patients with Frontotemporal Dementia and healthy controls
Methylation state of human post-mortem brain tissue from the frontal lobe of patients with Frontotemporal Dementia caused by mutations in GRN, MAPT and C9orf72 and healthy controls
ORGANISM(S): Homo sapiens 
2023-02-01 | E-MTAB-12674 | biostudies-arrayexpress
TranscriptomicssmRNA-sequencing of human post-mortem brain tissue of the frontal lobe from patients with Frontotemporal Dementia and healthy controls
Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking. The Risk and Modyfing Factors of Frontotempor...
ORGANISM(S): Homo sapiens 
2023-02-26 | E-MTAB-12731 | biostudies-arrayexpress
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