Sort   by:  
 Page size 
ProteomicsNeurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic
We previously discovered a sex-by-genotype defect in microglia function using a germline heterozygous knockout mouse model of Neurofibromatosis type 1 (Nf1+/- mice), in which only microglia from male Nf1+/- mice exhibited defects in purinergic signaling. Herein, we leveraged an unbiased proteomic ap...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD035881 | Pride
Purinergic signaling Sex differences Neurofibromin Nf1 Cortex Microglia Genetically engineered mice 
ProteomicsEnabling phenotypic drug discovery for neurological mitochondrial DNA disorders with patient-derived neural progenitor cells
Mitochondrial DNA (mtDNA) mutations predominantly cause neurological diseases. Searching for therapeutic strategies is hindered by the absence of viable neural model systems due to the challenges of engineering mtDNA. We demonstrate that neural progenitor cells (NPCs), rapidly obtained from human in...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080849 | MassIVE
Sort   by:  
 Page size