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GenomicsMLL1 is essential for the senescence-associated secretory phenotype
This SuperSeries is composed of the SubSeries listed below. Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory respon...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-78142 | biostudies-arrayexpress
GenomicsMLL1 is essential for the senescence-associated secretory phenotype [ChIP-Seq]
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the se...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78141 | biostudies-arrayexpress
ModelsSenescence Associated Secretory Phenotype
Cells and tissues are exposed to stress from numerous sources. Senescence is a protective mechanism that prevents malignant tissue changes and constitutes a fundamental mechanism of aging. It can be accompanied by a senescence associated secretory phenotype (SASP) that causes chronic inflammation. W...
11863 | Cell Collective
TranscriptomicsMLL1 is essential for the senescence-associated secretory phenotype [RNA-Seq]
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the se...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78138 | biostudies-arrayexpress
ProteomicsADAM19 Mediates Cellular Senescence and the Senescence-Associated Secretory Phenotype
ADAM19 Mediates Cellular Senescence and the Senescence-Associated Secretory Phenotype
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-03 | MSV000085224 | MassIVE
GenomicsThe lncRNA MIR31HG regulates the senescence associated secretory phenotype
The lncRNA MIR31HG regulates the senescence associated secretory phenotype
PRJNA604779 | ENA
GenomicsMLL1 is essential for the senescence-associated secretory phenotype
MLL1 is essential for the senescence-associated secretory phenotype
PRJNA312765 | ENA
TranscriptomicsExpression data from 7 Human Melanomas
Melanocytes within benign human nevi are the paradigm for tumor suppressive senescent cells in a pre-malignant neoplasm. These cells typically contain mutations in either the BRAF or N-RAS oncogene and express markers of senescence, including p16. However, a nevus can contain 10s to 100s of thousand...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-46817 | biostudies-arrayexpress
GenomicsSenescent microglia limit remyelination through the senescence associated secretory phenotype
Senescent microglia limit remyelination through the senescence associated secretory phenotype
PRJNA1117003 | ENA
ProteomicsThe lncRNA MIR31HG regulates the senescence associated secretory phenotype
Oncogene-induced senescence provides a barrier against malignant transformation. Senescent cells secrete pro-inflammatory cytokines, chemokines and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Paradoxically, the SASP can also negatively impact the neighb...
ORGANISM(S): Homo sapiens (Human) 
2021-03-02 | PXD017475 | Pride
Lncrna senescence mir31hg ybx1 sasp braf 
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