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MetabolomicsOxylipin biosynthesis reinforces cellular senescence through a RAS/p53 feedback loop and allows detection of senolysis
Not available
ORGANISM(S): Mus musculus 
ST001708 | MetabolomicsWorkbench
GenomicsPhotoactivatable senolysis with single-cell resolution reverses aging
Photoactivatable senolysis with single-cell resolution reverses aging
PRJNA882767 | ENA
GenomicsPhotoactivatable senolysis with single-cell resolution reverses aging
Photoactivatable senolysis with single-cell resolution reverses aging
PRJNA774276 | ENA
UnknownLocal senolysis in aged mice only partially replicates the benefits of systemic senolysis.
Not available
S-EPMC10104901 | biostudies-literature
TranscriptomicsPhotoactivatable senolysis with single-cell resolution reverses aging
Emerging evidence supports the use of pharmaceutical interventions to target senescent cells (SnCs) and induce their death (senolysis) to extend a healthy lifespan. The challenge then becomes how to achieve precise, broad-spectrum and tractable senolysis. To this end, we have designed a novel senoth...
ORGANISM(S): Mus musculus 
2022-09-24 | GSE213846 | GEO
UnknownEfficacy and limitations of senolysis in atherosclerosis.
Not available
S-EPMC9215197 | biostudies-literature
TranscriptomicsPhotoactivatable senolysis with single-cell resolution reverses aging
Cellular senescence is a crucial biological process associated with pathologies of aging. The elimination of senescent cells (SnCs) for the purpose to extend healthy lifespan has been supported by emerging evidence, which causes the exploration of drug approaches to induce SnCs death (senolysis). Th...
ORGANISM(S): Mus musculus 
2021-10-27 | GSE186522 | GEO
UnknownA senolysis-based theragnostic prodrug strategy towards chronic renal failure.
Not available
S-EPMC9580481 | biostudies-literature
UnknownAcceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes.
Not available
S-EPMC6610720 | biostudies-literature
UnknownApoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides.
Not available
S-EPMC8629786 | biostudies-literature
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