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Background Breast cancer patients who present in the early stage of disease are affected by metastasis to the axillary group of lymph nodes. The first among this group that is affected is called as sentinel lymph node, and metastasis to this lymph node is crucial for the staging of cancer and the qu...
ORGANISM(S): Homo sapiens (Human) 
2022-05-01 | PXD027668 | Pride
Sentinel REACT
Sentinel REACT
Endometrial cancer is the most common gynecological cancer worldwide. In women from developed countries, endometrial cancer is usually detected after the age of 60 years. Nearly 90% of the diagnosed cases are sporadic, while 10% are attributed to genetic factors. Thus, it is necessary to develop a d...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020410 | Pride
Cutaneous melanoma first metastasizes into sentinel lymph nodes that control the lymphatic drain from the area of the primary tumor. This observation is used clinically for melanoma patients with primary melanomas thicker than 1mm (tumor stage ≥T2a), for these patients sentinel lymph node biopsy has...
ORGANISM(S): Mus musculus 
Sentinel lymph node, the first node draining the primary tumor, is a key component of tumor microenvironment promoting immune tolerance. In melanoma, sentinel node is one of the most important prognostic factors and the most frequent site of regional metastasis. To unravel the immunomodulatory pathw...
ORGANISM(S): Homo sapiens 
Sentinel flaps recapitulate key inflammatory aspects of human face transplant rejection
Breast Cancer Remodels Lymphatics in Sentinel Lymph Nodes
Breast cancer remodels lymphatics in sentinel lymph nodes
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