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ProteomicsiTRAQ proteomics of sentinel lymph nodes for the identification of extra cellular matrix protein signatures that can flag metastasis in early breast cancer
Background Breast cancer patients who present in the early stage of disease are affected by metastasis to the axillary group of lymph nodes. The first among this group that is affected is called as sentinel lymph node, and metastasis to this lymph node is crucial for the staging of cancer and the qu...
ORGANISM(S): Homo sapiens (Human) 
2022-05-01 | PXD027668 | Pride
Itraq proteomics Extracellular matrix proteins Early breast cancer Sentinel lymph node metastasis 
TranscriptomicsTranscription profiling of human lymph node (sinuses) and tonsil (no sinuses) to identify signature genes that are prime candidates for mediating adhesion of tumor cells to sinusoidal cells
Lymph node vs. tonsil
ORGANISM(S): Homo sapiens 
2007-09-12 | E-GEOD-2665 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of tumor-positive sentinel lymph node biopsies from cutaneous melanoma patients
Sentinel lymph node, the first node draining the primary tumor, is a key component of tumor microenvironment promoting immune tolerance. In melanoma, sentinel node is one of the most important prognostic factors and the most frequent site of regional metastasis. To unravel the immunomodulatory pathw...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-39945 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in lymph nodes with metastasis of oral squamous cell carcinoma (OSCC)
Background: Cervical lymph node metastasis is a potent prognostic factor in oral squamous cell carcinoma (OSCC). However, lymph nodes resected by sentinel node biopsy or neck dissection are usually diagnosed by examining only one or two sections of the maximal cut surface. Accurate diagnosis of the ...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-70604 | biostudies-arrayexpress
TranscriptomicsTumor metastasis to lymph node requires YAP-dependent metabolic adaptation
In cancer patients, metastasis of tumors to sentinel lymph nodes (LN) predicts disease progression and often guides treatment decisions. The mechanisms underlying tumor LN metastasis are poorly understood. Using comparative transcriptomics and metabolomics analyses of primary and LN metastatic tumo...
ORGANISM(S): Mus musculus 
2019-02-09 | E-MTAB-7621 | biostudies-arrayexpress
GenomicsSpatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis
Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis
PRJNA1454945 | ENA
Unknown3-O-Acetyloleanolic acid inhibits VEGF-A-induced lymphangiogenesis and lymph node metastasis in an oral cancer sentinel lymph node animal model.
Not available
S-EPMC6034267 | biostudies-literature
UnknownEstablishment of a model of sentinel lymph node metastasis using immunodeficient swine.
Not available
S-EPMC6538626 | biostudies-literature
TranscriptomicsGene expression profiles of mouse sentinel lymph nodes (SLNs) in xenotransplanted and non tumor bearing CB17 SCID.
Cutaneous melanoma first metastasizes into sentinel lymph nodes that control the lymphatic drain from the area of the primary tumor. This observation is used clinically for melanoma patients with primary melanomas thicker than 1mm (tumor stage ≥T2a), for these patients sentinel lymph node biopsy has...
ORGANISM(S): Mus musculus 
2011-07-14 | E-GEOD-30688 | biostudies-arrayexpress
UnknownBiological ablation of sentinel lymph node metastasis in submucosally invaded early gastrointestinal cancer.
Not available
S-EPMC4351467 | biostudies-literature
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