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ProteomicsQuantitative phosphoproteomics analysis uncovers CDK1- and PAK2-mediated malignant signaling pathways in clear cell Renal Cell Carcinoma
Clear cell Renal Cell Carcinoma (ccRCC) is among the 10 most common cancers and causes more than 140,000 deaths worldwide every year. In order to elucidate the underlying molecular mechanisms orchestrated by phosphorylation modifications, we performed a comprehensive quantitative phosphoproteomics c...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028428 | Pride
Biomarkers Signaling pathways Drug targets Phosphoproteomics Renal cell carcinoma 
ProteomicsQuantitative proteomics identifies secreted diagnostic biomarkers as well as tumor-dependent prognostic targets for clear cell Renal Cell Carcinoma
Clear cell Renal Cell Carcinoma (ccRCC) is the third most common and most malignant urological cancer, with a 5-year survival rate of 10% for patients with advanced tumors. Here, we identified 10,160 unique proteins by in-depth quantitative proteomics, of which 955 proteins were significantly regula...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD024696 | Pride
Proteomics Urine Biomarkers Renal cell carcinoma Drug repurposing 
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