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TranscriptomicsSERBP1 iCLIP in mitotic and asynchronous cells with Blu577 treatment
In the associated paper, SERBP1 is shown to form granules in mitotic cells in a PKCɛ-dependent manner (M-bodies). We performed SERBP1 iCLIP in DLD1 cells that were either asynchronous or enriched for mitotic cells and after treatment with 2 hours of 500nM Blu577 or equivalent DMSO. We found that SER...
ORGANISM(S): Homo sapiens 
2021-10-05 | E-MTAB-10830 | biostudies-arrayexpress
GenomicsEnhanced crosslinking and immunoprecipitation of SERBP1 in Hela cells
Enhanced crosslinking and immunoprecipitation of SERBP1 in Hela cells
PRJNA656424 | ENA
GenomicsSERBP1 iCLIP in mitotic and asynchronous cells with Blu577 treatment
SERBP1 iCLIP in mitotic and asynchronous cells with Blu577 treatment
PRJEB46913 | ENA
GenomicsThe RNA binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation
RNA sequencing of U251 SERBP1 knockdown cells and RIP sequencing for the identification of SERBP1 targets in 293T cells
PRJEB35774 | ENA
TranscriptomicsEnhanced crosslinking and immunoprecipitation of SERBP1 in Hela cells
Purpose:We used eCLIP experiment to analyze binding profile of SERBP1 and its relationship with G4. Result: we found 505 high-confidence SERBP1 binding sites in Hela cells, and the analysis of sequence revealed transcriptome-wide enrichment of PQS in SERBP1-binding regions
ORGANISM(S): Homo sapiens 
2020-10-27 | GSE156015 | GEO
ProteomicsSERBP1–PCIF1 complex–controlled m6Am modification in S1HLGlu neurons is required for neuropathic pain in mice
Nerve injury-induced changes in pain-associated genes contribute to genesis of neuropathic pain and comorbid anxiety. Phosphorylated CTD interacting factor-1 (PCIF1)-triggered N6, 2′-O-dimethyladenosine (m6Am) mRNA modification represents an additional layer of gene regulation. However, the role of ...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD065634 |
GenomicsSERBP1 deacetylation inhibits ferroptosis to promote KSHV-induced cellular transformation by decaying lipoyltransferase 2 mRNA
SERBP1 deacetylation inhibits ferroptosis to promote KSHV-induced cellular transformation by decaying lipoyltransferase 2 mRNA
PRJNA1006410 | ENA
ProteomicsA genetically-encoded crosslinker screen identifies SERBP1 as a PKC substrate influencing translation and cell division
The PKC-regulated genome protective pathway provides transformed cells a failsafe to successfully complete mitosis. Despite the necessary role for Aurora B in this programme, it is unclear whether its requirement is sufficient or if other PKC cell cycle targets are involved. To address this, we deve...
ORGANISM(S): Homo sapiens (Human) 
2021-12-09 | PXD029091 | Pride
Human 
TranscriptomicsSERBP1 affects the apoptotic level by regulating the expression and alternative splicing of cellular and metabolic process genes in HeLa cells
RNA-binding proteins (RBPs) have important roles in orchestrating posttranscriptional regulation and modulating many tumorigenesis events. SERBP1 has been recognized as an important regulator in multiple cancers, while it remains unclear whether SERBP1-regulated gene expression at the transcriptome-...
ORGANISM(S): Homo sapiens 
2022-09-02 | GSE192950 | GEO
TranscriptomicsSERBP1 deacetylation inhibits ferroptosis to promote KSHV-induced cellular transformation by decaying lipoyltransferase 2 mRNA
Ferroptosis, a defensive strategy employed by the host to restrict pathogenic infections, has been implicated in the development and therapeutic responses of various types of tumors. However, the role of ferroptosis in KSHV-induced malignant tumors remains elusive. A steadily growing number of non-h...
ORGANISM(S): Rattus norvegicus 
2023-08-22 | GSE241111 | GEO
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