Serine/threonine kinases

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Unknown (1363)
Proteomics (914)
Transcriptomics (531)
Genomics (141)
Metabolomics (14)
Models (11)
Multiomics (7)
Other (5)
Clinical (1)

Organisms

Homo sapiens (757)
Mus musculus (194)
Rattus norvegicus (28)
Saccharomyces cerevisiae (27)
Arabidopsis thaliana (27)
Drosophila melanogaster (8)
Caenorhabditis elegans (8)
Candida albicans (7)
Schizosaccharomyces pombe (6)
Oryza sativa (5)
Gallus gallus (4)
Zea mays (4)
Danio rerio (3)
Bacillus subtilis subsp. subtilis str. 168 (3)
Mycobacterium tuberculosis (3)
Bos taurus (2)
Solanum lycopersicum (2)
Streptococcus mutans UA159 (2)
Toxoplasma gondii (2)
Oncorhynchus kisutch (1)
Staphylococcus aureus subsp. aureus NCTC 8325 (1)
Streptococcus sp. 'group A' (1)
Neisseria gonorrhoeae (1)
Human alphaherpesvirus 1 (1)
Bemisia tabaci (1)
Hordeum vulgare subsp. spontaneum (1)
Ciona intestinalis (1)
Podospora anserina (1)
Corynebacterium glutamicum (1)
Chlamydomonas reinhardtii (1)

Organisms

Homo sapiens (15)
Mus musculus (5)
Caenorhabditis elegans (3)
Zea mays (2)
Triticum aestivum (2)
Mycobacterium tuberculosis (2)
Ziziphus nummularia (1)
Streptococcus mutans UA159 (1)
Brassica napus (1)
Plasmodium falciparum (1)
Drosophila melanogaster (1)
Fungi (1)
Bacillus subtilis subsp. subtilis str. 168 (1)
Arabidopsis (1)
Oryza sativa (1)
Toxoplasma gondii (1)

Repository

biostudies-arrayexpress (529)
jPOST (458)
pride (332)
MassIVE (84)
EGA (63)
ENA (47)
geo (36)
iProX (14)
MetaboLights (14)
PanoramaPublic (14)
Cell Collective (9)
PeptideAtlas (7)
GPMDB (4)
PAXDB (4)
BioModels (2)

Tissue

Cell culture (90)
Epithelial cell (40)
Permanent cell line cell (24)
Brain (18)
Plant cell (16)
Kidney (12)
Blood cell (8)
Leaf (8)
T cell (8)
Blood (6)
Heart (6)
Liver (6)
Lung (6)
Skin (6)
Macrophage (5)
Malignant cell (5)
Whole body (5)
Platelet (4)
Colon (4)
Photosynthetic cell (4)
Primary cell (4)
Root (4)
B cell (3)
Cell suspension culture (3)
Diploid cell (3)
Fibroblast (3)
Lymph node (3)
Melanocyte (3)
Rosette (3)
Others (2)

Disease

Disease free (11)
Acute leukemia (8)
Colon cancer (6)
Breast cancer (6)
Melanoma (6)
Lung adenocarcinoma (5)
Non-small cell lung carcinoma (5)
Pancreatic ductal adenocarcinoma (5)
Hepatocellular carcinoma (4)
Not Available (4)
Lung cancer (4)
Pancreatic cancer (4)
Head and neck squamous cell carcinoma (3)
Malignant neoplasm of ovary (3)
Renal cell carcinoma (3)
Trypanosomiasis (3)
Alzheimer's disease (2)
Ataxia telangiectasia (2)
Brain cancer (2)
Cervix carcinoma (2)
Chagas disease (2)
Pheochromocytoma (1)
Extranodal NK/T-Cell Lymphoma derived cell line (1)
Ischaemia reperfusion injury (1)
Leukemia (1)
Not infected (1)
Acute promyelocytic leukemia (1)
Breast carcinoma (1)
Normal (1)
Stomach Neoplasms (1)

Technology Type

Mass Spectrometry (332)
Shotgun proteomics (226)
Bottom-up proteomics (61)
Data-dependent acquisition (43)
Affinity purification coupled with mass spectrometry proteomics (37)
Gel-based experiment (14)
Mass spectrometry (8)
Data-independent acquisition (8)
Top-down proteomics (7)
Mass spectrometry assay (6)
SWATH MS (6)
SRM/MRM (4)
Illumina HiSeq 2500, Illumina HiSeq 2000 (2)
Illumina HiSeq 2000 (2)
All-ion fragmentation (2)
Illumina MiSeq, ILLUMINA (1)
Illumina HiScanSQ, ILLUMINA (1)
Illumina HiSeq 4000, ILLUMINA (1)
Illumina HiSeq 2500, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 4000, Illumina HiSeq 2500, ILLUMINA (1)
HiSeq X Ten (1)
Illumina HiSeq 2500 (1)
Illumina HiSeq 2000, ILLUMINA (1)
Illumina Genome Analyzer II (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)
HDMSE (1)

Instrument Platform

Q Exactive (15)
Orbitrap Fusion Lumos (13)
Q Exactive Plus (13)
NextSeq 500 (11)
Illumina NovaSeq 6000 (9)
Illumina HiSeq 2000 (7)
LTQ Orbitrap Velos (7)
Orbitrap Fusion (7)
Q Exactive HF (7)
Illumina HiSeq 2500 (6)
Instrument (4)
HiSeq X Ten (2)
NextSeq 550 (2)
Coulter Automated Workstation Biomek i7 Hybrid (1)
RNeasy 96-well plate kit (1)
BD Rhapsody Express Instrument (1)
ScanArray 4000 [PerkinElmer] (1)
ScanArray [PerkinElmer] (1)
Illumina Genome Analyzer IIx (1)
G2565BA DNA microarray scanner [Agilent] (1)
ScanArray 4000XL [PerkinElmer] (1)
Illumina Genome Analyzer II (1)
None (1)
NA (1)
Ion Torrent Proton (1)
NextSeq 2000 (1)
Illumina HiSeq 1000 (1)
BGISEQ-500 (1)
Illumina MiSeq (1)
Illumina HiSeq 4000 (1)

Publication Date

2024 (483)
2010 (87)
2013 (71)
2014 (66)
2015 (65)
2022 (64)
2023 (62)
2008 (59)
2025 (56)
2021 (56)
2012 (56)
2026 (49)
2020 (48)
2016 (46)
2018 (45)
2019 (44)
2011 (41)
2009 (30)
2017 (25)
2007 (23)
2004 (6)
2005 (4)
2006 (1)

UNIPROT ID/AC

1FEH1_WHEAT (2)
4565.Traes_1AL_3CF82DD08.2 (2)
4565.Traes_1AL_3FDB6FDB4.1 (2)
4565.Traes_1AL_44FB362A9.2 (2)
4565.Traes_1AL_4E621A250.2 (2)
4565.Traes_1AL_51D597B92.1 (2)
4565.Traes_1AL_52E56C8D3.1 (2)
4565.Traes_1AL_53F3380AF.1 (2)
4565.Traes_1AL_5E2C30B46.1 (2)
4565.Traes_1AL_6B64D0E80.1 (2)
4565.Traes_1AL_72202D9DF.1 (2)
4565.Traes_1AL_738358449.1 (2)
4565.Traes_1AL_78CB13657.2 (2)
4565.Traes_1AL_7B509569F.1 (2)
4565.Traes_1AL_7CF571E9F.1 (2)
4565.Traes_1AL_7D6DC73FC.2 (2)
4565.Traes_1AL_9C2D7A0A6.1 (2)
4565.Traes_1AL_9EFC68149.1 (2)
4565.Traes_1AL_A47D32D30.1 (2)
4565.Traes_1AL_A69755144.1 (2)
4565.Traes_1AL_B15921488.1 (2)
4565.Traes_1AL_BAAF4391C.1 (2)
4565.Traes_1AL_BAB3D977B.1 (2)
4565.Traes_1AL_D06A380E9.2 (2)
4565.Traes_1AL_D39C4F23A.2 (2)
4565.Traes_1AL_D789B5634.1 (2)
Q15796 (1)
Q13485 (1)
P01137 (1)
P36897 (1)

ENSEMBL ID

ENSG00000170477 (2)
ENSG00000247315 (1)
ENSMUSG00000021039 (1)
ENSMUSG00000090272 (1)
ENSMUSG00000096833 (1)
ENSMUSP00000106991 (1)
ENSMUSP00000141097 (1)
ENSMUSP00000141542 (1)

CHEBI ID

CHEBI:15354 (4)
CHEBI:78320 (4)
CHEBI:16856 (4)
CHEBI:27897 (4)
CHEBI:6650 (4)
CHEBI:43474 (3)
CHEBI:15344 (3)
CHEBI:15919 (3)
CHEBI:18075 (3)
CHEBI:18211 (3)
CHEBI:16610 (3)
CHEBI:30754 (3)
CHEBI:30653 (3)
CHEBI:17858 (3)
CHEBI:16449 (3)
CHEBI:15940 (3)
CHEBI:16709 (3)
CHEBI:21547 (3)
CHEBI:16040 (3)
CHEBI:16811 (3)
CHEBI:16411 (3)
CHEBI:17287 (3)
CHEBI:7916 (3)
CHEBI:184023 (3)
CHEBI:17154 (3)
CHEBI:16235 (3)
CHEBI:28918 (3)
CHEBI:16919 (3)
CHEBI:16344 (3)
CHEBI:35222 (1)

Metabolite Name

UMP (5)
ADP (5)
Adenine (4)
Acetoacetate (3)
Carnosine (3)
UDP (3)
IMP (3)
DAMP (3)
DTMP (3)
Uric acid (3)
Inosine (3)
Glutathione (3)
Lactate (3)
AMP (3)
Arginine (3)
Creatine (3)
Choline (3)
Noradrenaline (2)
Oxaloacetate (2)
2-Ketohexanoic acid (2)
Ethanolamine (2)
N-acetyl-L-ornithine (2)
Hypotaurine (2)
6-Hydroxynicotinic acid (2)
Nicotinic acid (2)
D-Glucosamine (2)
Homoserine (2)
Folic acid (2)
Valine (2)
Tyrosine (2)

First Public Date

2014 (11)
2025 (10)
2022 (5)
2026 (4)
2024 (3)
2023 (3)
2021 (3)
2018 (3)
2017 (2)
2020 (1)
2016 (1)
2013 (1)

Modelling Approach

Partial differential equation model (1)
Ordinary differential equation model (1)

Study status

Suspended (1)

Lab affiliation

Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (9)
OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands (6)
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205 USA (5)
Distinguished Professor Associate Chair for Undergraduate Affairs (4)
Lineberger Comprehensive Cancer Center at UNC Chapel Hill (4)
Thoracic Oncology Molecular Medicine Program Moffitt Cancer Center Tampa, FL, USA (4)
University of Edinburgh (4)
Department of Biological Sciences, University of Alberta (3)
Department of Cell Biology, Harvard Medical School, Boston, MA, USA (3)
Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany (2)
Cancer Biology Department, Fox Chase Cancer Center, Philadelphia, PA, USA (2)
Chair of Proteomics and Bioanalytics, Technical University of Munich, Germany (2)
Department of Biochemistry, College of Medicine, University of Saskatchewan (2)
Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Canada (2)
Department of Infectious Diseases, University Hospital Zurich, University of Zurich, Zurich, Switzerland (2)
Department of Plant Systems Biology, University of Hohenheim, 70599 Stuttgart, Germany (2)
Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China (2)
Lanzhou Veterinary Research Institute (2)
Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch (2)
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark (2)
Shanghaitech University (2)
The Sainsbury Laboratory (2)
University Regensburg Biochemistry I Mass Spectrometry group (2)
University of Copenhagen Faculty of Health and Medical Sciences Novo Nordisk Foundation Center for Protein Research Proteomics Program (2)
University of Geneva, Faculty of Medicine, Geneva, Switzerland (2)
1 Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands, 2 Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands (1)
1 Department of Biology, University of Crete, 714 09 Heraklion, Crete, Greece 2 Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece (1)
1School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, NSW, 2308, Australia 2 Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia (1)
9Departments of Biochemistry and Biology and the Centre for Network Systems Biology, Boston University School of Medicine, Boston, MA, United States (1)
Aix-Marseille Univ, CNRS, FR3479, Proteomics facility of Institut de Microbilogie de la Méditerranée, Marseille Protéomique (1)

IsPrivate

False (2)

Submitter Keywords

Not Peer Reviewed (1)

Classification

bacteria (3)
protozoa (2)

Modification

4x(2)H labeled dimethylated L-lysine (2)
15.994915 (1)
2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)
57.021464 (1)
71.037114 (1)

Study type

Transcription profiling by array (394)
RNA-seq of coding RNA (58)
ChIP-seq (20)
Unknown experiment type (14)
Comparative genomic hybridization by array (7)
ChIP-chip by tiling array (5)
DNA-seq (5)
Cell line - High-throughput sequencing (4)
Transcription profiling by RT-PCR (3)
ChIP-chip by array (2)
Methylation profiling by array (2)
RNA-seq of coding RNA from single cells (2)
RNA-seq of non coding RNA (2)
Transcription profiling by SAGE (1)
Differential (1)
Cell line - Two-color microarray (1)
Cell line - One-color microarray (1)
Transcription profiling by tiling array (1)
Genotyping by array (1)
Spatial transcriptomics by high-throughput sequencing (1)
Other (1)
Proteomic profiling by array (1)
Methylation profiling by high throughput sequencing (1)
Observational (1)

Release Date

2010 (148)
2022 (124)
2015 (113)
2014 (107)
2021 (106)
2012 (105)
2013 (103)
2011 (99)
2019 (97)
2020 (93)
2008 (91)
2016 (83)
2018 (81)
2017 (81)
2025 (80)
2024 (80)
2023 (80)
2009 (69)
2007 (45)
2006 (20)
2026 (15)
2005 (14)
2004 (11)
2002 (10)
2003 (9)
2001 (9)
1998 (7)
1999 (5)
2000 (3)
1997 (3)

Location

United States (1)

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A delicate balance in cellular signaling is required for plants to distinguish mutualist from parasitic organisms in its environment. Mitogen-activated protein kinase (MAPK) cascades are one of the signaling modules that mediate transduction of extracellular microbial signals into appropriate cellul...

2017-08-25 | MTBLS441 | MetaboLights

Transcription profiling of mouse NIH3T3 cells over-expressing RNA-dependent serine/threonine protein kinase (PKR)PKR

Global analysis of gene expression in NIH3T3 cells over-expressing RNA-dependent serine/threonine protein kinase (PKR).

ORGANISM(S): Mus musculus

2008-06-15 | E-GEOD-682 | biostudies-arrayexpress

Transcriptome analysis of the eukaryotic-type ser/thr kinase PknB in Staphylococcus aureus

The function of the Staphylococcus aureus eukaryotic-like serine/threonine protein kinase PknB was investigated by transcriptome analysis using DNA-microarray technology and biochemical assays. The transcriptional profile reveals a strong regulatory impact of PknB on the expression of genes encoding...

ORGANISM(S): Staphylococcus aureus subsp. aureus NCTC 8325

2010-05-05 | E-GEOD-15346 | biostudies-arrayexpress

Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility

PRJNA1274935 | ENA

The role of serine/threonine-specific protein kinases in cyanobacteria - SpkB is involved in acclimation to fluctuating conditions in Synechocystis sp. PCC 6803

Protein phosphorylation via serine/threonine protein kinases (Spk) is a widespread mechanism to adjust cellular processes toward changing environmental conditions. To study their role(s) in cyanobacteria, we established a collection of 11 completely segregated spk mutants among the 12 annotated Spk’...

ORGANISM(S): Synechocystis sp. PCC 6803

2024-01-26 | PXD040383 | Pride

Comparative Phenotypic, Proteomic, and Phosphoproteomic Analysis Reveals Different Roles of Serine/Threonine Phosphatase and Kinase in the Growth, Cell Division, and Pathogenicity of Streptococcus suis

To investigate the influence of STP and STK on protein expression in S. suis, we performed a comparative proteomics analysis with the WT, Δstp, and Δstk strains using liquid chromatography mass spectrometry/mass spectrometry (LC-MS/MS).STK and STP are serine/threonine kinases and phosphatases, respe...

ORGANISM(S): Streptococcus suis SC84

2021-11-30 | PXD029994 | Pride

Streptococcus suis serine/threonine phosphatase serine/threonine kinase coordinated regulation growth cell division pathogenicit

A novel family of serine/threonine kinases participating in spermiogenesis.

Not available

S-EPMC2132653 | biostudies-literature

Phylogeny and Expansion of Serine/Threonine Kinases in Phagocytotic Bacteria in the Phylum Planctomycetota.

Not available

S-EPMC11032199 | biostudies-literature

PrrA modulation of Mycobacterium tuberculosis response to nitric oxide is critically regulated by serine/threonine protein kinases

PRJNA817808 | ENA

Mycobacterium tuberculosis Serine/Threonine Protein Kinases.

Not available

S-EPMC4242435 | biostudies-literature

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