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MetabolomicsCycloleucine disturbs functions of porcine Sertoli cells via modulating gene expression and metabolism

Cycloleucine (CL) is a methyl donor inhibitor. Our previous findings showed that CL could affect meiotic maturation and developmental potency of porcine oocytes by reducing nucleic acid N6-methyladenosine (m6A) epigenetic modification level. However, the effects of CL on porcine male reproduction...

2025-09-13 | MTBLS12990 | MetaboLights
MetabolomicsMelatonin enhances function of porcine immature Sertoli cells via modulating gene expression and metabolism

Melatonin (MT), a neurohormone synthesized and secreted primarily by the pineal gland, is of vital function to animal reproduction. However, the effect of MT treatment on porcine immature Sertoli cells (iSCs) remains unclear. Here, MT treatment (10 nM, 36 h) could elevate mitochondrial function a...

2025-01-06 | MTBLS11126 | MetaboLights
MetabolomicsMetabolite of esculetin plays an important role in cytotoxic effects induced by chloroquine on porcine immature Sertoli cells

Chloroquine (CQ) is widely used in the therapy against malarial, tumor and recently the COVID-19 pandemic, as a lysosomotropic agent to inhibit the endolysosomal trafficking in the autophagy pathway. We previously reported that CQ (20 µM, 36 h) could reprogram transcriptome and impair multiple si...

2024-07-08 | MTBLS9273 | MetaboLights
MetabolomicsProfile of key metabolites and identification of HMGCS1-DHEA pathway in porcine Sertoli cells treated by Vitamin C
Vitamin C (Ascorbic acid, AA), as vital micro-nutrient, plays an essential role for male animal reproduction. Previously, we showed that vitamin C reprogrammed the transcriptome and proteome to change phenotypes of porcine immature Sertoli cells (iSCs). Here, we used LC-MS-based non-targeted metabol...
2024-07-31 | MTBLS9673 | MetaboLights
TranscriptomicsAndrogen-Responsive microRNAs in mouse Sertoli Cells
Although decades of research have established that androgen is essential for spermatogenesis, androgen’s mechanism of action remains elusive. This is in part because only a few androgen-responsive genes have been definitively identified in the testis. Here, we report that microRNAs—small, noncoding ...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-37679 | biostudies-arrayexpress
TranscriptomicsGene expression comparison between different stages of endogenous Sertoli cells and induced embryonic Sertoli cells derived from MEFs and TTFs
To compare the transcriptional profile of endogenous Sertoli cells from different Stage of Sertoli cell development (embryonic, immature, mature) to the transcriptionla profile of induced embryonic Sertoli cells derived from MEFs or TTFs we employed the agilent whole genome microarray Keywords: Exp...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-39648 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression between MEFs, MEFs (NWD), immature Sertoli cells and mature Sertoli cells
To compare the the genomic profile of MEFs, immature Sertoli, mature Sertoli cells, and MEFs (NWD) after infection of Nr5a1, Wt1 and Dmrt1 after 1 month of dox exposure. MEFs (NWD) were infected with Nr5a1, Wt1 and Dmrt1 and were exposed to dox for 1 month. MEFs, immature Sertoli and mature Sertoli ...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-39649 | biostudies-arrayexpress
ProteomicsMultiomics Approach to Profiling Development of the Spermatogonial Stem Cell Niche Focused on Sertoli cell Maturation
Spermatogonial stem cells are the foundation of spermatogenesis and as such can serve as a tool for the treatment of infertility in prepubertal cancer survivors. Spermatogonial stem cells are unique as they develop from primordial germ cells (PGCs), which colonize the developing tubules as immature ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-02-24 | PXD037764 | Pride
Metabolic microenvironment Niche development Lipid metabolism Sertoli cell maturation 
TranscriptomicsTranscription profiling time series of Rattus norvegicus Sertoli cells treated with follicle-stimulating hormone
Spermatogenesis requires the presence of functional somatic Sertoli cells in the seminiferous tubules of the testis. Sertoli cells provide support and factors necessary for the successful progression of germ cells into spermatozoa. Sertoli cells are regulated to a large degree by the glycoprotein ho...
ORGANISM(S): Rattus norvegicus 
2007-12-12 | E-GEOD-509 | biostudies-arrayexpress
ProteomicsProteomic and phosphoproteomic profiles of Sertoli cells in buffalo
Sertoli cells provide nutrients and support for germ cell differentiation and maintain a stable microenvironment for spermatogenesis. Comprehensive identification of Sertoli cellular proteins is important in understanding spermatogenesis. In this study, we performed an integrative analysis of the pr...
ORGANISM(S): Bos taurus (Bovine) 
2021-05-07 | PXD024984 | Pride
Lc-ms/ms Sertoli cell Buffalo 
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