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TranscriptomicsArx acts as a key selector gene of the ventral telencephalon mainly through its repression transcriptional activity
The homeobox containing gene Arx is expressed during ventral telencephalon development and it is required for correct GABAergic interneuron tangential migration from the ganglionic eminences to the olfactory bulbs, cerebral cortex and striatum. Its human ortholog is associated with a variety of neur...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-12956 | biostudies-arrayexpress
TranscriptomicsDIRECT CONVERSION OF FIBROBLASTS INTO FUNCTIONAL ASTROCYTES BY DEFINED TRANSCRIPTION FACTORS
Direct cell reprogramming has enabled the direct conversion of skin fibroblasts into functional neurons and oligodendrocytes using a minimal set of cell lineage-specific transcription factors. This approach has substantial advantages since it is rapid and simple, generating the cell type of interest...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-59018 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of E14.5 control and Tbr2 fl/fl;Foxg1::Cre cortices
The abscence of TBR2 gene in human leads to microcephaly. This condition is mimicked by the specific ablation of the murine gene in developing cerebral cortex. Herein we compared gene expression in control and Tbr2 cKO in E14.5 cerebral cortices. This approach represents a useful tool to identify th...
ORGANISM(S): Mus musculus 
2016-09-08 | E-GEOD-63619 | biostudies-arrayexpress
GenomicsTbr2 and Neurog2 transcription factor binding sites in E14.5 WT cerebral cortices
To date, speculations on the molecular roles of Tbr2 transcription factor during specification, maintenance and differentiation of cortical specific Intermediate Neural Progenitors are coming from the analysis of loss- and gain-of-function experiments. However since its capacity to bind the DNA to e...
ORGANISM(S): Mus musculus 
2016-09-08 | E-GEOD-63620 | biostudies-arrayexpress
TranscriptomicsRapid conversion of fibroblasts into functional forebrain GABAergic interneurons by direct genetic reprogramming
Transplantation of GABAergic interneurons (INs) can sustain long-standing benefits in animal models of epilepsy and other neurological disorders. In a therapeutic perspective, a renewable source of functional GABAergic INs is needed. Here, we identified five factors (Foxg1, Sox2, Ascl1, Dlx5 and Lhx...
ORGANISM(S): Mus musculus 
2015-12-15 | E-GEOD-74065 | biostudies-arrayexpress
TranscriptomicsMicroarray of MyT1 Gain-of-Function in NS5
Here we performed a microarray experiment on samples of adherent cultures of mouse neural stem cells (NS5 cell line) expressing an inducible version of the transcription factor MyT1 (MyT1-V5 TetON) under normal growth conditions and after 4 hours of treatment by doxycyline. This resulted in the gene...
ORGANISM(S): Mus musculus 
2016-09-09 | E-MTAB-4335 | biostudies-arrayexpress
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