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MetabolomicsThe oncoprotein SET promotes serine-derived one-carbon metabolism by regulating SHMT2 enzymatic activity
Cancer cells frequently reprogram one-carbon metabolic pathways to fulfill their vigorous demands of biosynthesis and antioxidant defense for survival and proliferation. Dysfunction of oncogenes or tumor suppressor genes is critically involved in this process, but the precise mechanisms by which can...
2025-04-22 | MTBLS11711 | MetaboLights
MetabolomicsA benchmark spike-in data set for biomarker identification in metabolomics
The development and the validation of innovative approaches for biomarker selection are of paramount importance in many -omics technologies. Unfortunately, the actual testing of new methods on real data is difficult, because in real data sets, one can never be sure about the “true” biomarkers. In th...
2013-10-24 | MTBLS59 | MetaboLights
MetabolomicsA data set of 255000 randomly selected and manually classified extracted ion chromatograms for evaluation of peak detection methods

Nontargeted mass spectrometry (MS) has become an important method over the last years in the fields of metabolomics and environmental research. While more and more algorithms and workflows become available to process a large number of data sets nontargeted, there still exist few manually evaluate...

2020-05-26 | MTBLS1455 | MetaboLights
MetabolomicsInvestigation of metabolomic blood biomarkers for detection of adenocarcinoma lung cancer (training set)
Not available
ORGANISM(S): Homo sapiens 
ST000385 | MetabolomicsWorkbench
MetabolomicsIdentification of pre-diagnostic lipid sets associated with liver cancer risk using untargeted lipidomics and chemical set analysis – a nested case-control study within the ATBC cohort

In pre-disposed individuals, a reprogramming of the hepatic lipid metabolism may support liver cancer initiation. We conducted a high-resolution mass spectrometry based untargeted lipidomics analysis of pre-diagnostic serum samples from a nested case-control study (219 liver cancer cases and 219 ...

2023-09-18 | MTBLS7776 | MetaboLights
MetabolomicsTargeted Cholesterol Profiling of Myelin to Enhance Recovery of Function after SCI. Second Set of Samples
Not available
ORGANISM(S): Mus musculus 
ST000857 | MetabolomicsWorkbench
MetabolomicsAnalysis of the human adult urinary metabolome variations with age, body mass index and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. ('Sacurine' data set)

Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological infor...

2017-01-20 | MTBLS404 | MetaboLights
MetabolomicsLipid Data Analyzer: Decision rule set development by lipid standards of known constituent fatty acyl and/or alkyl/1-alkenyl chains and their respective sn-positions (Control experiment 1)

Lipid Data Analyzer (LDA; http://genome.tugraz.at/lda2) provides automated and reliable annotation of lipid species and their molecular structures in high-throughput data from chromatography-coupled tandem mass spectrometry using embedded rule sets. Using various low- and high-resolution mass spe...

2017-10-27 | MTBLS394 | MetaboLights
TranscriptomicsClassifier analysis of gene expression profiles reveals a discriminatory gene set for soil containing different metals
Environmental pollution is a worldwide problem, and metals are the largest group of contaminants in soil. Microarray toxicogenomic studies with ecologically relevant organisms such as springtails, supplement traditional ecotoxicological research, but are presently rather descriptive. Classifier anal...
ORGANISM(S): Folsomia candida 
2010-02-04 | E-GEOD-19353 | biostudies-arrayexpress
TranscriptomicsMolecular prediction of gastrulation stages with small extra-embryonic gene-set
Axis specification in mouse is determined by a sequence of reciprocal interactions between embryonic and extra-embryonic tissues so that a few extra-embryonic genes appear as ‘patterning’ the embryo. Considering these interactions as essential, but lacking in most mammals the genetically driven appr...
ORGANISM(S): Bos taurus 
2010-06-24 | E-GEOD-13013 | biostudies-arrayexpress
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