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TranscriptomicsA gene expression signature associated with K-Ras addiction reveals regulators of EMT and tumor cell survival
K-Ras mutations occur frequently in epithelial cancers. Using shRNAs to deplete K-Ras in lung and pancreatic cancer cell lines harboring K-Ras mutations, two classes were identified—lines that do or do not require K-Ras to maintain viability. Comparing these two classes of cancer cells revealed a g...
ORGANISM(S): Homo sapiens 
2009-03-06 | E-GEOD-15126 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of NSCLC cell lines upon TGFb-induced epithelial-mesenchymal transition (EMT)
Epithelial-mesenchymal transition has been implicated in tumor metastasis, cancer drug resistance and cancer stem cell features. In this study, we examined gene expression profiles of three non-small cell lung cancer cell lines, before and after experimentally induced EMT. We modeled epitheial-mese...
ORGANISM(S): Homo sapiens 
2014-11-19 | E-GEOD-49644 | biostudies-arrayexpress
TranscriptomicsThe effect of androgen deprivation on human prostate xenograft tumor LuCaP35
Androgen deprivation is a standard of care front-line therapy for human prostate cancer, however, majority of patients will eventally develop resistance to androgen deprivation. In this study, using a human prostate cancer xenograft model -LuCaP35, we examiend the gene expression changes after castr...
ORGANISM(S): Homo sapiens 
2011-12-06 | E-GEOD-33316 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse prostate stem cells
The mouse prostate tissue exhibits strong power of regeneration, indicating the exisistence of prostate stem cells. Previously we showed that a single mouse prostate cells defined by Lin-CD44+CD133+Sca-1+CD117+ phenotype can generate a prostate after transplantation in vivo. In this study, we compar...
ORGANISM(S): Mus musculus 
2011-12-06 | E-GEOD-33317 | biostudies-arrayexpress
UnknownIntegrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.
Not available
S-EPMC1635390 | biostudies-literature
TranscriptomicsA genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
In a genome-wide screen of human cancer cell lines, we identified homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. Among these, PARD3 is disrupted in cell lines and primary tumors from squamous carcinomas and glioblastomas. Reco...
ORGANISM(S): Homo sapiens 
2011-11-03 | E-GEOD-20306 | biostudies-arrayexpress
UnknownUnprovoked Stabilization and Nuclear Accumulation of the Naked Mole-Rat p53 Protein.
Not available
S-EPMC7181817 | biostudies-literature
Unknownp190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4.
Not available
S-EPMC2426943 | biostudies-literature
UnknownErbB2 Is Necessary for ErbB4 Ligands to Stimulate Oncogenic Activities in Models of Human Breast Cancer.
Not available
S-EPMC3278901 | biostudies-literature
Unknownp190A RhoGAP is a glycogen synthase kinase-3-beta substrate required for polarized cell migration.
Not available
S-EPMC2475707 | biostudies-literature
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