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TranscriptomicsA gene expression signature associated with K-Ras addiction reveals regulators of EMT and tumor cell survival
K-Ras mutations occur frequently in epithelial cancers. Using shRNAs to deplete K-Ras in lung and pancreatic cancer cell lines harboring K-Ras mutations, two classes were identified—lines that do or do not require K-Ras to maintain viability. Comparing these two classes of cancer cells revealed a g...
ORGANISM(S): Homo sapiens 
2009-03-06 | E-GEOD-15126 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of NSCLC cell lines upon TGFb-induced epithelial-mesenchymal transition (EMT)
Epithelial-mesenchymal transition has been implicated in tumor metastasis, cancer drug resistance and cancer stem cell features. In this study, we examined gene expression profiles of three non-small cell lung cancer cell lines, before and after experimentally induced EMT. We modeled epitheial-mese...
ORGANISM(S): Homo sapiens 
2014-11-19 | E-GEOD-49644 | biostudies-arrayexpress
TranscriptomicsThe effect of androgen deprivation on human prostate xenograft tumor LuCaP35
Androgen deprivation is a standard of care front-line therapy for human prostate cancer, however, majority of patients will eventally develop resistance to androgen deprivation. In this study, using a human prostate cancer xenograft model -LuCaP35, we examiend the gene expression changes after castr...
ORGANISM(S): Homo sapiens 
2011-12-06 | E-GEOD-33316 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse prostate stem cells
The mouse prostate tissue exhibits strong power of regeneration, indicating the exisistence of prostate stem cells. Previously we showed that a single mouse prostate cells defined by Lin-CD44+CD133+Sca-1+CD117+ phenotype can generate a prostate after transplantation in vivo. In this study, we compar...
ORGANISM(S): Mus musculus 
2011-12-06 | E-GEOD-33317 | biostudies-arrayexpress
TranscriptomicsA genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
In a genome-wide screen of human cancer cell lines, we identified homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. Among these, PARD3 is disrupted in cell lines and primary tumors from squamous carcinomas and glioblastomas. Reco...
ORGANISM(S): Homo sapiens 
2011-11-03 | E-GEOD-20306 | biostudies-arrayexpress
GenomicsGenentech_cell_line_SNP
SNP array data for 668 cancer cell lines
EGAD00010000951 | EGA
Genomicsena-DATASET-Genentech-11-09-2014-19:43:22:926-1 - samples
RNAseq and exome sequencing data of gastric cancer cell lines.
EGAD00001001013 | EGA
Genomicsena-DATASET-GENENTECH-24-01-2014-01:33:01:945-58 - samples
This dataset contains RNA sequencing data for 675 cancer cell lines. RNA libraries were made with the TruSeq RNA Sample Preparation kit (Illumina) according to the manufacturer protocol. The libraries were sequenced on an Illumnia HiSeq 2000
EGAD00001000725 | EGA
GenomicsRNA sequencing and Illumina 2.5M SNP array data collected from 675 commonly used human cancer cell lines.
Tumor-derived cell lines have served as vital models to advance our understanding of oncogene function and therapeutic response1. Although substantial effort has been directed to defining the genomic constitution of cancer cell line panels2–4, the transcriptome – which represents the active program ...
EGAS00001000610 | EGA
TranscriptomicsRNA-seq of 675 commonly used human cancer cell lines
Tumor-derived cell lines have served as vital models to advance our understanding of oncogene function and therapeutic response1. Although substantial effort has been directed to defining the genomic constitution of cancer cell line panels24, the transcriptome which represents the active program of...
ORGANISM(S): Homo sapiens 
2014-11-25 | E-MTAB-2706 | biostudies-arrayexpress
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