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TranscriptomicsVitamin D receptor (VDR) target genes in THP-1 monocytic leucemia cells
The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is a direct regulator of gene transcription, since it is the only high affinity natural ligand of the transcription factor vitamin D receptor (VDR). Transcriptome-wide analysis of THP-1 human monocyte-like cells had i...
ORGANISM(S): Homo sapiens 
2015-04-26 | E-GEOD-60102 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of vitamin D receptor (VDR) target genes in THP-1 monocytic leucemia cells
Identification of primary target genes of vitamin D receptor (VDR) in an immune-related cellular model (THP-1 cells) to study, in conjunction with VDR binding data from ChIP-seq, the genome-wide mechanisms of transcriptional regulation by VDR. THP-1 cells were treated 4 h either with 0.1% ethanol (v...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-27270 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of human monocytic THP-1 cell treated with 1α,25-dihydroxyvitamin D3 or Trichostatin A and the combination of both
The nuclear hormone 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) regulates its target genes via activation of the transcription factor vitamin D receptor (VDR) far more specifically than the chromatin modifier trichostatin A (TsA) via its inhibitory action on histone deacetylases. We selected the thro...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-36323 | biostudies-arrayexpress
GenomicsCTCF ChIP-seq in human monocytic THP-1 cells
ChIP-seq for the insulator protein CTCF in THP-1 cells after stimulation with the the natural VDR ligand 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) THP-1 cells were treated for 24 h with 100 nM 1,25(OH)2D3 before ChIP assay
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-69962 | biostudies-arrayexpress
TranscriptomicsRNA-seq 1,25(OH)2D3 time course in THP-1 cells
gene expression profiling by RNA-seq in THP-1 cells treated with 1,25(OH)2D3 for 2.5-24 h three independent experiments of 1,25(OH)2D3 time course in THP-1 cells
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-69284 | biostudies-arrayexpress
GenomicsFAIRE-seq 1,25(OH)2D3 time course in THP-1 cells
Assessment of regions of open chromatin by FAIRE-seq in THP-1 cells treated with 1,25(OH)2D3 for 0-48 h Three independent experiments of 1,25(OH)2D3 time course in THP-1 cells
ORGANISM(S): Homo sapiens 
2016-07-04 | E-GEOD-69297 | biostudies-arrayexpress
GenomicsShort-term time course of the effects of 1α,25-dihydroxyvitamin D3 treatment on open chromatin regions in THP-1 monocytic leukemia cells
Open chromatin regions have been shown to associate with the location of transcriptiotal enhancers, i.e., the binding locations of DNA-binding transcription factors. To investigate the effects of short-term treatment by the nuclear hormone 1α,25-dihydroxyvitamin D3 (VD), a specific ligand of the tr...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-40075 | biostudies-arrayexpress
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