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MetabolomicsComparative Analysis of Host Metabolic Alterations in Murine Malaria Models with Uncomplicated or Severe Malaria

Malaria varies in severity, with complications ranging from uncomplicated to severe malaria. Severe malaria could be attributed to peripheral hyperparasitemia or cerebral malaria. The metabolic interactions between the host and Plasmodium species are yet to be understood during these inf...

2022-09-14 | MTBLS4387 | MetaboLights
MetabolomicsGut Bacteroides act in a microbial consortium to cause susceptibility to severe malaria

Malaria, caused by Plasmodium species, remains a significant cause of morbidity and mortality globally. Gut bacteria can influence the severity of malaria, but the contribution of specific bacteria to the risk of severe malaria is unknown. Here, multiomics approaches demonstrate specific...

2023-09-13 | MTBLS3449 | MetaboLights
TranscriptomicsPaired whole blood human transcription profiles from children with severe malaria and mild malaria
Whole blood transcriptomes from a longitudinal study of 5 Malawian children who first present with severe Plasmodium falciparum malaria, and return in one month with mild malaria We used microarrays to identify transcripts that were associated with each clinical presentation. A blood sample was tak...
ORGANISM(S): Homo sapiens 
2012-01-11 | E-GEOD-33811 | biostudies-arrayexpress
MetabolomicsTowards improving point-of-care diagnosis of non-malaria febrile illness: a metabolomics approach
Background: Non-malaria febrile illnesses such as bacterial bloodstream infections (BSI) are a leading cause of disease and mortality in the tropics. However, there are no reliable, simple diagnostic tests for identifying BSI or other severe non-malaria febrile illnesses. We hypothesized that differ...
2016-03-17 | MTBLS315 | MetaboLights
MetabolomicsMaHPIC Experiment HuB - Metabolomics analysis of human plasma from patients infected with Plasmodium falciparum and P.vivax for discovery of diagnostic markers of malaria
MaHPIC Experimental Description:
This study is based on archived plasma from samples collected between 2011 and 2014. Patients in Thailand who were infected with Plasmodium falciparum (30 subjects), P. vivax (30 subjects), co-infected with P. falciparum and P. viv...
2018-09-05 | MTBLS664 | MetaboLights
TranscriptomicsDual RNA-seq of peripheral blood from Gambian children with severe or uncomplicated Plasmodium falciparum malaria
This study examined the differences in human and parasite gene expression pattern between children with severe malaria and those with uncomplicated malaria through a dual RNA-seq approach. Peripheral blood samples were collected which contained substantial numbers of parasites that required no RNA e...
ORGANISM(S): Homo sapiens 
2018-06-20 | E-MTAB-6413 | biostudies-arrayexpress
TranscriptomicsGene expression profiling after vaccination with the RTS,S candidate malaria vaccine in a controlled human malaria infection study
RTS,S is the sole candidate vaccine shown to provide protection against infection to malaria-naive adults challenged with mosquito-borne homologous falciparum malaria and protection against infection and clinical and severe disease to volunteers in malaria-endemic Africa who were exposed to diverse ...
ORGANISM(S): Homo sapiens 
2017-04-27 | E-MTAB-4629 | biostudies-arrayexpress
TranscriptomicsExpression data from whole blood samples of Rwandan adults with mild malaria with matched sample thirty days later (convalescence)
Host factors governing mild disease in adults who have developed clinical immunity to Plasmodium falciparum may provide insights for disease altering vaccine or interventions, to prevent severe malaria We used microarrays of whole blood samples during mild malaria and compared them in a paired analy...
ORGANISM(S): Homo sapiens 
2014-12-19 | E-GEOD-64338 | biostudies-arrayexpress
TranscriptomicsAcute Lung Injury In Experimental Malaria
Although respiratory distress is a common complication of severe malaria, little is known about the underlying molecular basis of lung dysfunction. Animal models have provided powerful insights into the pathogenesis of severe malaria syndromes such as cerebral malaria; however, no model of malaria-i...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-9497 | biostudies-arrayexpress
ProteomicsMultiplexed Quantitative Proteomics Provides Mechanistic Cues for Malaria Severity and Complexity
Management of severe malaria remains a critical global challenge. In this study, using a multiplexed quantitative proteomics pipeline we systematically investigated the plasma proteome alterations in non-severe and severe malaria patients. We identified a few parasite proteins in severe malaria pati...
ORGANISM(S): Homo sapiens (Human) 
2020-11-06 | PXD014991 | Pride
Multiplexed quantitative proteomics Severe malaria Infectious disease 
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