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TranscriptomicsGene expression profiling of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a solid neoplasm exhibiting aggressive tumor phenotypes with unpredictable biological behavior and usually a very unfavorable prognosis. The comprehension of the molecular basis of the variability within this cancer disease should lead to the development of sat...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-9792 | biostudies-arrayexpress
TranscriptomicsHistone Deacetylase Inhibitor prevents cell growth in Burkitt's lymphoma by regulating PI3K/Akt pathways and leading to up regulation of micro RNA-143, -145 and -101
In this study we analyzed gene expression profiles in a well-characterized BL cell line upon treatment with HDACi combined with chemotherapy. The impact on gene expression regulation was broader when HDACi was combined with chemotherapy, than when either therapy was used alone. As expected, treatmen...
ORGANISM(S): Homo sapiens 
2014-06-20 | E-GEOD-48399 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of PRAME-positive and PRAME-negative osteosarcoma samples
Preferentially Expressed Antigen in Melanoma (PRAME) is frequently overexpressed in a wide variety of cancers and it has been proposed as prognostic marker for clinical outcome. It belongs to a class of non-mutated genes whose expression seems to be mostly restricted to tumor cells. Osteosarcoma is ...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-8079 | biostudies-arrayexpress
TranscriptomicsMonocyte-Derived Dendritic Cells Differ in Cytoskeleton and Cell Adhesion-Related Expression Depending on VEGF Exposure
The inadequate function of the antigen presenting cells, such as dendritic cells (DCs) in cancer is one of the major factors leading to compromised anti-tumor immune response. Cell-to-cell interactions and cell migration are essential features of the immunological response in cancer. Vascular endoth...
ORGANISM(S): Homo sapiens 
2011-12-30 | E-GEOD-16072 | biostudies-arrayexpress
TranscriptomicsGene expression in peripheral mononuclear cells from septic patients secondary to community acquired pneumonia: patterns of gene expression and outcomes
Sepsis is defined as a systemic inflammatory response secondary to a proven or suspected infection. Mechanisms governing this inflammatory response have been shown to be complex and dynamic, involving cross-talking among diverse signaling pathways. However, current knowledge on mechanisms underlying...
ORGANISM(S): Homo sapiens 
2014-06-20 | E-GEOD-48080 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing of small RNA transcriptomes and DNA microarrays reveal critical biological features targeted by microRNAs in cell models used for squamous cell cancer research
Background The implication of post-transcriptional regulation by microRNAs in molecular mechanisms underlying cancer disease is well documented. However, their interference at the cellular level is not fully explored. Functional in vitro studies are fundamental for the comprehension of their role; n...
ORGANISM(S): Homo sapiens 
2013-12-30 | E-GEOD-41436 | biostudies-arrayexpress
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