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TranscriptomicsAdipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization
The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown. Here we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereb...
ORGANISM(S): Mus musculus 
2013-11-21 | E-GEOD-36031 | biostudies-arrayexpress
TranscriptomicsThe ER-Associated Degradation Adapter Protein Sel1L Regulates Triglyceride Metabolism via Lipoprotein Lipase
Sel1L is an adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum-associated degradation (ERAD), but its physiological role in a cell-type-specific manner remains unclear. Here we show that mice with adipocyte-specific Sel1L deficiency are resistant to diet-induced obesity and exhibit ...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-56918 | biostudies-arrayexpress
TranscriptomicsThe IRE1α-XBP1 Pathway of the Unfolded Protein Response is Required for Adipogenesis
Signaling cascades during adipogenesis culminate in the expression of two essential adipogenic factors, PPARγ and C/EBPα. Here we demonstrate that the IRE1α-XBP1 pathway, the most conserved branch of the unfolded protein response (UPR), is indispensable for adipogenesis. Indeed, XBP1-deficient ...
ORGANISM(S): Mus musculus 
2010-06-19 | E-GEOD-15771 | biostudies-arrayexpress
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