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ProteomicsProteogenomic Characterization Reveals Tumorigenesis and Progression of Lung Adenocarcinoma Manifested as Subsolid Nodules
Lung adenocarcinoma (LUAD) radiologically displayed as subsolid nodules (SSNs) is prevalent. However, precise clinical management of SSNs requires thorough understanding of its tumorigenesis and progression. Here, we analyzed 66 LUAD displayed as SSNs covering 3 histological stages including adenoca...
ORGANISM(S): Homo sapiens (Human) 
2025-02-10 | PXD046637 | Pride
Lung adenocarcinoma  proteomic Phosphoproteomic  glycoproteomic 
UnknownSingle-cell analyses reveal metastasis mechanism and microenvironment remodeling of lymph node in intrahepatic cholangiocarcinoma.
Not available
S-EPMC11876886 | biostudies-literature
UnknownCholangiocarcinoma: anatomical location-dependent clinical, prognostic, and genetic disparities.
Not available
S-EPMC6989985 | biostudies-literature
TranscriptomicsThe ER-Associated Degradation Adapter Protein Sel1L Regulates Triglyceride Metabolism via Lipoprotein Lipase
Sel1L is an adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum-associated degradation (ERAD), but its physiological role in a cell-type-specific manner remains unclear. Here we show that mice with adipocyte-specific Sel1L deficiency are resistant to diet-induced obesity and exhibit ...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-56918 | biostudies-arrayexpress
TranscriptomicsThe IRE1α-XBP1 Pathway of the Unfolded Protein Response is Required for Adipogenesis
Signaling cascades during adipogenesis culminate in the expression of two essential adipogenic factors, PPARγ and C/EBPα. Here we demonstrate that the IRE1α-XBP1 pathway, the most conserved branch of the unfolded protein response (UPR), is indispensable for adipogenesis. Indeed, XBP1-deficient ...
ORGANISM(S): Mus musculus 
2010-06-19 | E-GEOD-15771 | biostudies-arrayexpress
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