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UnknownWidening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency.
Not available
S-EPMC9063678 | biostudies-literature
UnknownData set on Lassa fever in post-conflict Sierra Leone.
Not available
S-EPMC6369334 | biostudies-literature
GenomicsDendritic Cell Fate is Determined by BCL11A
Here we confirm an essential requirement for the BCL11A transcription factor in fetal pDC development, and for the first time demonstrate this lineage specific requirement in the adult organism. Genome-wide analyses of BCL11A DNA binding and expression revealed that BCL11A regulates transcription of...
ORGANISM(S): Homo sapiens 
2014-02-15 | E-GEOD-55043 | biostudies-arrayexpress
TranscriptomicsMyeloma IRF4 target genes - Agilent
The goal of this gene expression study was to identify genes whose expression depends on the transription factor IRF4 by knocking down it's expression using shRNA in two IRF4+ myeloma cell lines. Keywords: time series design Two myeloma lines were analyzed over a time course of IRF4-targeted shRNA i...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-9067 | biostudies-arrayexpress
GenomicsGenomewide occupancy of the synovial sarcoma-associated SYT-SSX2 oncoprotein in C2C12 myoblasts
Synovial sarcoma is a rare malignancy that is characterized by the presence of a chromosomal translocation t(X;18). This genetic abnormality results in the fusion of 2 transcriptional co-regulators, SYT and SSX, which have been shown to mediate transcriptional activation and repression, respectivel...
ORGANISM(S): Mus musculus 
2011-09-26 | E-GEOD-26564 | biostudies-arrayexpress
TranscriptomicsIRF4 and Myeloma
Using RNA interference to identify IRF4 target genes. Keywords: time series design Gene expression was analyzed using Lymphochip cDNA spotted arrays. Myeloma cell lines were infected with control (shluc, Cy3) or shIRF4 (Cy5) constructs, and changes in gene expression were monitored over time after i...
ORGANISM(S): Homo sapiens 
2008-07-07 | E-GEOD-8958 | biostudies-arrayexpress
GenomicsIRF4 ChIP-on-chip for Myeloma Cell Lines
To identify IRF4 transcription factor binding on chromatin at 5' regulatory regions of genes in myeloma cell line models. Keywords: binding site identification design Formaldehyde cross-linked, sonicated chromatin is prepared from cell lines Kms12 (test) and Ly19 (control). Chromatin immunoprecipate...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-9367 | biostudies-arrayexpress
TranscriptomicsPrimary B Cells acute activation
To identify early activation genes in primary human B cells. Keywords: time series design Primary B cells (Cy5) are compared to a reference pool of RNA (Cy3) over a time course of stimulation with anti-Ig. Two independent unstimulated samples were analyzed.
ORGANISM(S): Homo sapiens 
2008-09-01 | E-GEOD-9030 | biostudies-arrayexpress
TranscriptomicsGenome-wide maps of primary and processed start-sites of transcripts revealed mechanism controlling in vivo stoichiometry of protein complex in bacteria
Here a differential mRNA-sequencing (dRNA-Seq) strategy was employed to distinguish transcriptional start-sites (TSs) and post-transcriptional processed sites (PSs) of transcripts in the cellulolytic mesophile Clostridium cellulolyticum. PS-harboring genes usually  encode heteromultimeric complexes...
ORGANISM(S): [Clostridium] cellulolyticum 
2015-04-27 | E-GEOD-57652 | biostudies-arrayexpress
TranscriptomicsMature B cell versus Plasma Cell Gene Expression
Comparing the gene expression of primary human B cell populations using human Lymphochip cDNA spotted arrays. Primary samples (Cy5) were compared to a reference pool of polyA+ RNA (Cy3). Keywords: cell type comparison design PolyA+ RNA was extracted from primary B cell populations (Cy5) and compared...
ORGANISM(S): Homo sapiens 
2008-08-31 | E-GEOD-8959 | biostudies-arrayexpress
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