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TranscriptomicsGlobal Analysis of Post-transcriptional Gene Expression in Arsenite-treated Human BJ Fibroblasts
Arsenic is a potent environmental toxin and a cause of numerous health problems. Most studies have assumed that arsenic-induced changes in mRNA levels result from effects on gene transcription. The influence of arsenic on post-transcriptional regulation, another important locus of gene expression ...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-57051 | biostudies-arrayexpress
TranscriptomicsThe transcription factors Snail and Slug activate the TGF-B signaling pathway in breast cancer
Gene expression profiling to determine transcriptome changes following Snail or Slug expression in MCF-7 breast cancer cells Samples were isolated in three biological replicates for microarray analysis. Four MCF-7 breast cancer cell subsets: MCF-7(untreated), MCF-7 (with Control adenovirus), MCF-7 ...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-29672 | biostudies-arrayexpress
TranscriptomicsDNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas
Elevated DNA methylation in the first intronic region of the BCL6 locus in B cell lymphomas enforces transcription of the BCL6 gene Promoter tiling arrays were used to investigate the distribution of DNA methylation near the promoter region of BCL6 locus Comparison of DNA methylation at promoter reg...
ORGANISM(S): Homo sapiens 
2010-08-20 | E-GEOD-22884 | biostudies-arrayexpress
TranscriptomicsRNA polymerase is poised for activation across the genome
Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA ...
ORGANISM(S): Drosophila melanogaster 
2007-11-11 | E-GEOD-6714 | biostudies-arrayexpress
TranscriptomicsB lymphocyte activation induces DNA methylation reprogramming and establishes a common epigenetic signature in memory B and plasma cell compartments [gene expression profiling]
DNA methylation profiling of human B cell populations representing a developmental series before and after immune activation. The B cells are derived from inflamed tonsils. The B cells were already activated in vivo in patients, therefore there was no need to stimulate the B cells after isolation. ...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-24863 | biostudies-arrayexpress
TranscriptomicsRunx2 Transcriptome of Prostate Cancer Cells: Insights into Invasiveness and Bone Metastasis
Background: Prostate cancer (PCa) cells preferentially metastasize to bone at least in part by acquiring osteomimetic properties. Runx2, an osteoblast master transcription factor, is aberrantly expressed in PCa cells, and promotes their metastatic phenotype. The transcriptional programs regulated by...
ORGANISM(S): Homo sapiens 
2010-12-26 | E-GEOD-24261 | biostudies-arrayexpress
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