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ProteomicsProteomic Analysis of Rap1A GTPase Signaling-Deficient C57BL/6 Mouse Pancreas and Functional Studies Identify an Essential Role of Rap1A in Pancreas Physiology
The Ras-related Rap1A GTPase is implicated in pancreas β-cell insulin secretion, and is stimulated by the cAMP sensor Epac2, a guanine exchange factor and activator of Rap1 GTPase. In this study we examined the differential proteomic profiles by nanoLC-ESI-MS/MS of pancreata from C57BL/6 Rap1A-defic...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052896 | Pride
Oral glucose tolerance test  insulin tolerance test Glucose-stimulated insulin secretion Pancreas  intracellular signaling  rap1a-gtpase  gene knockout  differential expression  nanolc-esims/ms  ero1lβ expression 
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