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ProteomicsUnique Protein Interaction Networks Define The Chromatin Remodeling Module of The NuRD Complex
The combination of four proteins and their paralogues including MBD2/3, GATAD2A/B, CDK2AP1, and CHD3/4/5, which we refer to as the MGCC module, form the chromatin remodeling module of the Nucleosome Remodeling and Deacetylase (NuRD) complex. To date, mechanisms by which the MGCC module acquires para...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025263 | Pride
Chahp complex Mass spectrometry Chromatin remodeling Ncor complex Protein-protein interactions Nurd complex Aggregation protein region 
ProteomicsY chromosome-located gene, lysine-specific demethylase 5D, associated with prostate cancer
The objective of Human Y Chromosome Proteome Project is to map and annotate all proteins encoded by genes on the MSY sequences. Lysine (K)-specific demethylase 5D (KDM5D) is located on the AZFb region of Y chromosome and encode for a JmjC-domain-containing protein. Changes in KDM5D transcript level ...
ORGANISM(S): Homo sapiens (Human) 
2015-08-05 | PXD000416 | Pride
Label-free shotgun proteomics Human y chromosome Kdm5d 
ProteomicsIntrinsically Disordered Regions in Chromodomain Helicase DNA-binding (CHD) Proteins Shape Distinct Protein Interaction Networks
Metazoans employ chromodomain helicase DNA-binding (CHD) enzymes to reposition nucleosomal DNA for transcription and replication. The CHD family consists of nine distinct members (CHD1-9) that possess highly conserved chromo and ATPase domains. These domains are flanked by poorly characterised N- an...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD055009 | Pride
Dna helicase Chromatin remodelers Transcription Intrinsically disordered regions Aggregation prone regions Protein-protein interactions 
ProteomicsDDX3Y and other Male Specific Region of Y Chromosome Genes may modulate neuronal differentiation and mediate various biological pathways in addition to their well described role regulating spermatogenesis
Human tissue based proteomics projects are challenging due to low abundance of proteins and tissue specificity of protein expression. In this study, we aimed to develop a cell-based approach to profile the male specific region of the Y chromosome (MSY) proteins. First, we profiled the expression of ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-10 | MSV000083949 | MassIVE
ProteomicsDDX3Y and other Male Specific Region of Y Chromosome Genes may modulate neuronal differentiation and mediate various biological pathways in addition to their well described role regulating spermatogenesis
Human tissue based proteomics projects are challenging due to low abundance of proteins and tissue specificity of protein expression. In this study, we aimed to develop a cell-based approach to profile the male specific region of the Y chromosome (MSY) proteins. First, we profiled the expression of ...
ORGANISM(S): Homo sapiens (Human) 
2015-09-17 | PXD002428 | Pride
Rna metabolism. Chromosome centric human proteome project (c-hpp) Ddx3y Apoptosis Cell-based human proteome project Cell cycle Shotgun proteomics Y-linked genes 
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