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Activity-based protein profiling (ABPP) of stereoisomerically defined sets of electrophilic compounds (‘stereoprobes’) offers a versatile way to discover covalent ligands for proteins in native biological systems. Here we report the synthesis and chemical proteomic characterization of stereoprobes b...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD060339 | Pride
Herein we describe a new enantioselective route for the synthesis of all stereoisomers of 2,3-disubstituted azetidines. This approach uses simple strain release functionalization of preformed 1-azabicyclobutanes (ABBs), which enables installation of a wide array of nucleophiles at the C3-position. C...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD055926 | Pride
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