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TranscriptomicsThe Human Airway Epithelial Basal Cell Transcriptome
Background. The human airway epithelium consists of 4 major cell types: ciliated, secretory, columnar and basal cells. During natural turnover and in response to injury, the airway basal cells function as stem / progenitor cells for the other airway cell types. The objective of this study is to bett...
ORGANISM(S): Homo sapiens 
2011-06-10 | E-GEOD-24337 | biostudies-arrayexpress
TranscriptomicsDo Airway Epithelium Air-liquid Cultures Represent the In Vivo Airway Epithelium Transcriptome?
Human airway epithelial cells cultured in vitro at air-liquid interface (ALI) form a pseudostratified epithelium that forms tight junctions and cilia, and produces mucin, and are widely used as a model of differentiation, injury, and repair. To assess how closely the transcriptome of ALI epithelium ...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-18637 | biostudies-arrayexpress
TranscriptomicsModulation of Cystatin A Expression in Human Airway Epithelium Related to Genotype, Smoking COPD and Lung Cancer
Cystatin A (gene: CSTA), is up-regulated in non-small-cell lung cancer (NSCLC) and dysplastic vs normal human bronchial epithelium. In the context that chronic obstructive pulmonary disease (COPD), a small airway epithelium (SAE) disorder, is independently associated with NSCLC (especially squamous ...
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-22047 | biostudies-arrayexpress
TranscriptomicsSmoking-dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of COPD
Background: When exposed to specific stimuli, macrophages exhibit distinct activation programs, M1 and M2 polarization, that define macrophage function as inflammatory/immune effectors or anti-inflammatory/tissue remodeling cells, respectively. Due to their position on the lung epithelial surface, a...
ORGANISM(S): Homo sapiens 
2009-08-09 | E-GEOD-13896 | biostudies-arrayexpress
TranscriptomicsSmoking-induced Disarray of the Apical Junctional Complex Gene Expression Architecture in the Human Airway Epithelium
The apical junctional complex (AJC), composed of tight junctions and adherens junctions, is essential for maintaining epithelial barrier function. Since cigarette smoking and chronic obstructive pulmonary disease (COPD), the major smoking-induced disease, are both associated with increased lung epit...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-GEOD-20257 | biostudies-arrayexpress
TranscriptomicsAirway Basal Cells of Healthy Smokers Express an Embryonic Stem Cell Signature Relevant to Lung Cancer
Activation of the human embryonic stem cell (hESC)-signature genes has been observed in various epithelial cancers. In this study, we found that the hESC signature is selectively induced in the airway basal stem/progenitor cell population of healthy smokers (BC-S), with a pat-tern similar to that ac...
ORGANISM(S): Homo sapiens 
2014-09-09 | E-GEOD-19722 | biostudies-arrayexpress
TranscriptomicsSmoking Dysregulates the Human Airway Basal Cell Transcriptome at COPD-linked Risk Locus 19q13.2
Rationale: Genome-wide association studies (GWAS) and candidate gene studies have identified a number of loci linked to susceptibility of chronic obstructive pulmonary disease (COPD), a smoking-related disorder that originates in the airway epithelium. Objectives: Since airway basal cell (BC) stem/p...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-47718 | biostudies-arrayexpress
TranscriptomicsPOU2AF1 Functions in the Human Airway Epithelium to Regulate Expression of Host Defense Genes [RNA-Seq]
In the process of seeking novel lung host defense regulators by analyzing genome-wide RNA sequence data from normal human airway epithelium, we detected expression of POU2AF1, a known transcription co-factor previously thought to be expressed only in lymphocytes. Lymphocyte contamination of human ai...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-60989 | biostudies-arrayexpress
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