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UnknownMixing and flow-induced nanoprecipitation for morphology control of silk fibroin self-assembly.
Not available
S-EPMC8982335 | biostudies-literature
GenomicsChem-Seq of chemical derivatives in MM1S cells
An ability to map the global interactions of a chemical entity with chromatin genome-wide could provide new insights into the mechanisms by which a small molecule perturbs cellular functions. we developed a method that uses chemical derivatives and massively parallel DNA sequencing (Chem-Seq) to ide...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-44098 | biostudies-arrayexpress
TranscriptomicsWhiA and WhiB of Streptomyces venezuelae depend on each other for binding DNA
WhiB regulon, as determined by ChIP-Seq turned out to be identical to the WhiA regulon leading to the speculation that the two proteins might be required to work together to bind DNA. In this experiment WhiA ChIP-Seq was done in a whiB deletion background and, WhiB ChIP-Seq was done in a whiA deleti...
ORGANISM(S): Streptomyces venezuelae 
2021-07-01 | E-MTAB-10673 | biostudies-arrayexpress
TranscriptomicsChIP-Seq to determine the binding sites of the transcription factor WhiB in the genome of Streptomyces venezuelae
WhiB is the founding member of a family of proteins (the WhiB-like [Wbl] family) that carry a [4Fe-4S] iron-sulfur cluster. It is essential for the process of developmentally controlled cell division leading to sporulation in Streptomyces species. This ChIP-Sea was carried out to determine unambiguo...
ORGANISM(S): Streptomyces venezuelae 
2021-06-25 | E-MTAB-10648 | biostudies-arrayexpress
GenomicsThe developmental potential of iPSCs is greatly influenced by the selection of the reprogramming factors
Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4 and Myc (OSKM) into somatic cells. Though iPSCs are pluripotent, they frequently exhibit high variation in their quality as measured by chimera contribution and tetraploid (4n) complementation. Thus, im...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-59569 | biostudies-arrayexpress
TranscriptomicsMutation of the cysteine residues that coordinate the WhiB [4Fe-4S] cluster prevents in vivo DNA binding by both WhiB and WhiA
The purpose of this experiment was to show that the iron-sulphur cluster ([4Fe-4S]) of whiB is essential for the DNA binding by WhiB and WhiA. The \\"serine version of whiB\\" mentioned below is a whiB in which the 4 cysteine residues which coordinate the [4Fe-4S] cluster were mutated to serines. Ch...
ORGANISM(S): Streptomyces venezuelae 
2021-08-16 | E-MTAB-10818 | biostudies-arrayexpress
GenomicsExpression, ChIP-chip, and ChIP-Seq data from REH and SEM leukemia cell lines [ChIP-Seq]
MLL-fusion proteins are potent inducers of cancer in hematopoietic cells, where they are known to cause changes in global gene expression. How MLL-fusion proteins interact with the genome has not been established, so we have limited understanding of the pathway by which these proteins generate aberr...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-38338 | biostudies-arrayexpress
GenomicsChIP-seq of the HOXA9 and MEIS1 transcription factors in SEM cells.
SEM cells were established from the peripheral blood of a 5-year-old girl in relapse with acute lymphoblastic leukaemia (ALL). SEM cells exhibit the t(4;11) chromosomal rearrangement, which leads to production of the MLL-AF4 fusion protein. Hematopoietic transcription factors including HOXA9 and MEI...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-38339 | biostudies-arrayexpress
GenomicsIntronic Non-CG DNA Hydroxymethylation and Alternative mRNA Splicing in Honey Bees
Honey bee non-CG DNA hydroxymethylation is enriched in the introns, which supplements previous findings that honey bee CG DNA methylation is enriched in exons. Bisulfite sequencing combined with Pvu-Seq to distinguish 5-methylcytosine from 5-hydroxymethylcytosine and RNA-Seq
ORGANISM(S): Apis mellifera scutellata 
2013-09-19 | E-GEOD-50990 | biostudies-arrayexpress
GenomicsCpG Island Structure and Trithorax/Polycomb Chromatin Domains in Human Cells
TrxG and PcG complexes play key roles in the epigenetic regulation of development through H3K4me3 and H3K27me3 modification at specific sites throughout the human genome, but how these sites are selected is poorly understood. We find that in pluripotent cells, clustered CpG islands at genes predict ...
ORGANISM(S): Homo sapiens 
2012-07-06 | E-GEOD-39137 | biostudies-arrayexpress
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