The aim of the experiment was to explore the RUNX2 genomic functions in the papillary thyroid carcinoma. To this end, we performed Chromatin Immunoprecipitation followed by deep-sequencing using an antibody against RUNX2, RNA-Polymerase II and Histone Marks (H3K27ac, H3K4me1, H3K4me3) in MDA-T41 th...
Multiple myeloma (MM) cell line treated with an inhibitor to EZH2/EZH1 (UNC1999), DNA methylation inhibitor (5-azacytidine), and a combination of both.
to find out the lnc122(precursor of miR-122) role as an independent lncRNA, we designed the lnc122-/miR-122+ Huh7 cells with Lenti-CRISPRi_lnc122 + lenti-CAG-miR-122 combination. lenti-CRISPRi_lnc122 suppresses endogenous lnc122 as well as miR-122 but we add back the miR-122 ectopically.
Various studies have established the role of genetics in the development of type 2 diabetes mellitus (T2DM) across population groups with a reported heritability of 30–70%. These studies highlight the effect of interethnic variability in genetic susceptibility and risk for complications of T2DM. The...
Various studies have established the role of genetics in the development of type 2 diabetes mellitus (T2DM) across population groups with a reported heritability of 30–70%. These studies highlight the effect of interethnic variability in genetic susceptibility and risk for complications of T2DM. The...
