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TranscriptomicsFoie WTS vs WT
Transcriptional and polysomal analysis of mice liver hepatocytes after 4-hour refeeding as compared to overnight starved controls.
ORGANISM(S): Mus musculus 
2013-01-24 | E-MEXP-3522 | biostudies-arrayexpress
TranscriptomicsEliane_IL2.Rapa bis
Administration of low-dose IL-2 prevents and cures type 1 diabetes (T1D) in NOD mice by boosting pancreatic regulatory T cells (Tregs) and is currently being evaluated in humans. Here, to improve treatment efficacy we tested higher IL-2 doses that, despite further boosting Tregs, rapidly precipitate...
ORGANISM(S): Mus musculus 
2013-12-10 | E-MEXP-3789 | biostudies-arrayexpress
TranscriptomicsS6K_RiBi
Transcriptional analysis of concequent lack of rpS6 kinase activity in mice livers hepatocytes due to deletion of S6 kinases 1 and 2 (S6K1 and S6K2).
ORGANISM(S): Mus musculus 
2013-01-16 | E-MEXP-3518 | biostudies-arrayexpress
TranscriptomicssiRNA profiling of human synovial fibroblasts depleted for clusterin
Analysis of synoviocytes cell form patients suffering of Rheumatoid arthritis and depleted for clusterin by siRNA knockdown. Note: this experiment was reloaded into ArrayExpress on 2nd December 2009 because the incorrect array design had originally been selected. The identifiers in the datafile wer...
ORGANISM(S): Homo sapiens 
2009-12-04 | E-TABM-653 | biostudies-arrayexpress
TranscriptomicsOJeanJean_eRF3a_ATF4
We previously showed that eRF3a depletion in the human colon carcinoma cell line HCT116 p53+/+ induces mTOR signaling pathway inhibition (Chauvin et al., 2007) suggesting that eRF3a belongs to a regulatory mechanism that modulate mTOR activity. However, this mechanism and the precise role of eRF3a r...
ORGANISM(S): Homo sapiens 
2012-08-30 | E-MEXP-3512 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse CD4+ GFP+ (tregs) and CD4+ GFP- (Teffs) cells treated with IL-2
To obtain the molecular signature of the effect that the IL-2 therapeutic dose induces on T cells in vivo, we performed gene array analysis. Since it was critical to perform this analysis on highly purified Tregs and Teffs, and also because activated Teffs can acquire CD25 expression, we used GFP-Fo...
ORGANISM(S): Mus musculus 
2011-03-21 | E-MEXP-2689 | biostudies-arrayexpress
TranscriptomicsHeterogeneous CD3 expression levels in differing T-cell subsets account for in vivo anti-CD3-mediated immune resetting
The tolerogenic anti-CD3 monoclonal antibodies (anti-CD3) are promising compounds for the treatment of type 1 diabetes (T1D). Anti-CD3 administration induces transient T-cell depletion both in preclinical and in clinical studies. Notably, said depletion mainly affects CD4+ but not CD8+ T cells. More...
ORGANISM(S): FoxP3-GFP NOD mouse 
2015-01-19 | E-MTAB-2437 | biostudies-arrayexpress
UnknownValidation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.
Not available
S-EPMC8855527 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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