Shh - OmicsDI

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Mus musculus (350)
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UNIPROT ID/AC

P10523 (2)
Q15465 (2)
Q13635 (2)
P18537 (2)
P49841 (2)
P56704 (2)
P01133 (2)
Q02248 (1)
Q86TH3 (1)
Q147T7 (1)
Q99835 (1)
B4NUI3 (1)
Q92793 (1)
Q3MHS8 (1)
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CHEBI ID

CHEBI:114785 (2)
CHEBI:25750 (2)
CHEBI:36080 (2)
CHEBI:15422 (2)
CHEBI:16761 (2)
CHEBI:18287 (1)
CHEBI:15996 (1)
CHEBI:17552 (1)

IsPrivate

False (7)

First Public Date

2014 (92)
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Modelling Approach

Ordinary differential equation model (5)
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Study type

Transcription profiling by array (192)
RNA-seq of coding RNA (48)
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RNA-seq of coding RNA from single cells (9)
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Animal - High-throughput sequencing (2)
Human - High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
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Release Date

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2004 (3)
2002 (3)
1998 (3)
2001 (2)
2000 (2)
1999 (1)
1997 (1)

Lab affiliation

Head of the Curie Institute Mass Spectrometry Platform (3)
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA (2)
Insitute for Physiologcial Chemistry and Pathobiochemistry University of Muenster Waldeyerstraße 15 48149 Münster Germany (1)
Facutly of Science, University of Geneva (1)
Department of Pediatrics, Division of Pediatric Hematology/Oncology and Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA (1)
Molecular Biology of Retinal Degenerations Institute for Ophthalmic Research Eberhard-Karls University of Tuebingen (1)
Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany (1)
Department of Pharmacology | UW School of Medicine Institute of Stem Cell and Regenerative Medicine | University of Washington, Seattle, USA (1)
Department of Biomedical Sciences Faculty of Medicine and Health Science Macquarie University (1)
University of Geneva, Switzerland (1)
Department of Biology, University of Napoli Federico II, Napoli, Italy (1)
Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK (1)
Mass Spectrometry and Proteomics facility (LSMP) Institut Curie PSL Research University FRANCE (1)
Institute for Molecular Medicine I, Medical Faculty, Heinrich-Heine-University Duesseldorf, Universitaetsstrasse 1, 40225 Duesseldorf, Germany (1)
Section of Mass Spectrometric Proteomics, University Medical Center Hamburg eppendorf (1)
Laboratory of Molecular Neuro-Oncology, Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland Department of Neurosurgery, Cantonal Hospital St.Gallen, Rorschacher Strasse 95, 9007 St.Gallen, Switzerland (1)
Proteomics facility, Central Science Laboratory, University of Tasmania (1)
Department of Biochemistry and Molecular Biology Hollings Cancer Center Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425; (1)
Tumor Biology Research Program, Basic Research Unit, Research Department, Children’s Cancer Hospital in Egypt 57357, Cairo, Egypt (1)
Max Planck Institute of Biochemistry (1)

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Alterations in SHH signal transduction introduce a state of hypometabolism in sporadic Parkinson's disease

Not available

ORGANISM(S): Homo sapiens

ST002389 | MetabolomicsWorkbench

Transcription profiling of rat cerebellar granular cells cultured in the presence of Shh for 24h and then pulsed with Bmp2 or vehicle for up to 24h

Proliferating cerebellar granular cells were cultured in presence of Shh for 24h (3ug/ml) and then pulsed for additional 24h with Bmp2 or vehicle. Cells then were lysed and mRNA extracted. Microarray data from cells treated with Bmp2 was referred to the control not treated with Bmp2.

ORGANISM(S): Rattus norvegicus

2007-06-07 | E-MEXP-1129 | biostudies-arrayexpress

Requirement for Shh and Fox family genes at different stages in sweat gland development

Sweat glands play a fundamental role in thermal regulation in man, but the molecular mechanism of their development remains unknown. To initiate analyses, we compared the model of Eda mutant Tabby mice, in which sweat glands were not formed, to wild-type mice. We inferred developmental stages and c...

ORGANISM(S): Mus musculus

2010-05-05 | E-GEOD-14907 | biostudies-arrayexpress

RAS/MAPK activation drives resistance to Smo inhibition, metastasis and tumor evolution in Shh pathway-dependent tumors

Aberrant Shh signaling promotes tumor growth in diverse human cancers. The importance of Shh signaling is particularly evident in medulloblastoma and basal cell carcinoma (BCC), where inhibitors targeting the Shh pathway component Smoothened (Smo) show great therapeutic promise. However, the emergen...

ORGANISM(S): Mus musculus

2015-07-22 | E-GEOD-69359 | biostudies-arrayexpress

Requirement for Shh and Fox family genes at different stages in sweat gland development (Adult)

ORGANISM(S): Mus musculus

2010-05-05 | E-GEOD-14877 | biostudies-arrayexpress

Requirement for Shh and Fox family genes at different stages in sweat gland development (P5)

ORGANISM(S): Mus musculus

2010-05-05 | E-GEOD-14876 | biostudies-arrayexpress

Requirement for Shh and Fox family genes at different stages in sweat gland development (E15.5)

ORGANISM(S): Mus musculus

2010-05-05 | E-GEOD-14870 | biostudies-arrayexpress

Requirement for Shh and Fox family genes at different stages in sweat gland development (P1)