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MetabolomicsLow chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, co...
2021-10-06 | MTBLS2148 | MetaboLights
ProteomicsPsychological stress exacerbates vitiligo via dysregulated proteolysis of substance P and MRGPRX2-dependent mast cell activation
Although psychological stress has been anecdotally related to flare-ups of vitiligo, the underlying mechanism(s) has remained poorly defined. In this study, we investigated whether substance P (SP) and its proteolytic fragments (SP1-9 and SP1-7) modulate the anti-melanocyte immune response under str...
ORGANISM(S): Homo Sapiens 
2025-11-07 | PXD070437 |
ProteomicsKLF16 enhances stress tolerance of colorectal carcinomas by modulating nucleolar homeostasis and translational reprogramming
Translational reprogramming is part of the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress, which acts to the advantage of cancer growth and development in different stress conditions. But the mechanism of ER stress-related translational reprogramming in colorectal carcinoma...
ORGANISM(S): Homo Sapiens 
2022-05-16 | PXD033930 |
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