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ProteomicsIdentification of regulators of polyploidization presents therapeutic targetsfor treatment of AMKL
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Go...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-01-27 | MSV000078536 | MassIVE
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
ProteomicsEugenol modulates the NOD1- NF-κB signaling pathway via targeting NF-κB protein in triple breast cancer cells
Background: The most aggressive subtype of breast cancer, triple-negative breast cancer (TNBC), has a worse prognosis and a higher probability of relapse since there is a narrow range of treatment options. Identifying and testing potential therapeutic targets for the treatment of TNBC is of high pri...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039305 | Pride
Proteomics Target protein. Eugenol Cmap Darts Triple-negative breast cancer 
MetabolomicsSingle-cell metabolic fingerprints discover a cluster of circulating tumor cells with distinct metastatic potential

Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC count may not be the 'best' indicator of metastatic risk because their heterogeneity is generally neglected. In this study, we develop a molecular typing system to predict colorectal cancer metastasis potent...

2023-08-21 | MTBLS5028 | MetaboLights
ProteomicsMyo19 Interacting Proteins IP-MS
This project is aimed to detect the interacting proteins of mitochondria-tageting actin motor Myo19.
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD033198 | Pride
Myo19 ip-ms 
MetabolomicsRectal microbiomes and serum metabolomics reveal changes in serum antioxidant status and immune responses of Dezhou donkeys in late gestation to parturition

Background: Parturition is a critical event in the reproductive cycle of dairy animals, accompanied by multiple physiological changes in sex hormones, metabolism, antioxidant capacity and immune function. However, the changes in the rectal microbiota and metabolic products of Jennies from late ge...

2025-08-27 | MTBLS12897 | MetaboLights
ProteomicsParagorgia papillata and Chrysogorgia sp. skeletal proteome
This project contains raw bone proteome data for Paragorgia papillata and Chrysogorgia sp.
ORGANISM(S): Octocorallia 
2024-10-19 | PXD056993 |
ProteomicsProteomic analysis revealed the potential role of MAGE-D2 in therapeutic targeting of triple-negative breast cancer
Triple negative breast cancer (TNBC) is one of the most aggressive molecular subtypes in breast cancer. Due to the lack of effective therapeutic targets, the clinical outcomes for TNBC patients remain poor. Here, we performed an integrated proteomic analysis including bioinformatic analysis of prote...
ORGANISM(S): Homo Sapiens 
2023-03-07 | PXD040645 |
ProteomicsCCL20/CXCL5 regulates the stemness of anaplastic thyroid cancer stem cells via NF-kB pathway
The mechanism of CCL20/CXCL5 regulating anaplastic thyroid cancer cancer stem cells to promote the progression of thyroid cancer
ORGANISM(S): Homo Sapiens 
2023-11-13 | PXD046889 |
ProteomicsA brain signaling framework for stress-induced depression and ketamine treatment elucidated by phosphoproteomics
Depression is a common affective disorder characterized by significant and persistent low mood.Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, is reported to have a rapid and durable antidepressant effect.
ORGANISM(S): Mus Musculus 
2019-11-18 | PXD016302 |
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